酒精相关内分泌障碍及肝脏疾病

Alcohol related endocrine disorders and alcoholic liver disease

目的:介绍酒精所致的内分泌障碍及酒精性肝病(ALD)的机制及治疗进展。方法:对近年文献进行复习。结果:本文对酒精对内分泌系统的影响及所致的功能障碍(尤其是对HPA轴、HPT轴及性腺轴的影响)的机制、治疗的进展,酒精性肝病的发生机制、分类及治疗进展进行了介绍。结论:酒精可导致内分泌系统功能障碍及肝功能障碍,酒精引起的障碍早期或可通过戒酒逆转,但晚期病变(如肝硬化)则很难逆转。对晚期患者,除戒酒之外,支持治疗是主要的手段。

Objective： To review the updates on alcohol-related endocrine disorders and alcoholic liver disease mechanism and treatment. Methods： Literature review and hand-picked literature. Results： We review the mechanism （ especially the influence on the HPA axis, the HPT axis and the gonad axis） and treatment of alcohol related endocrine disorders, and the mechanism, classification and treatment of alcoholic liver disease （ALD）. Conclusion： Alcohol can cause endocrine disorders and liver damage. While some disorders are reversible by stop drinking, some （such as cirrhosis） are not. For advanced or patients in terminal stage, in addition to stopping drinking, supportive care plays an important role.