CIK细胞对肺腺癌化疗不良反应的影响

Efficacy of CIK cells on the adverse reactions of lung adenocarcinoma caused by chemotherapy

目的研究细胞因子诱导的杀伤细胞（CIK细胞）对肺腺癌患者化疗中不良反应的影响。方法选取2011年10月-2013年10月就诊于我院、经病理学证实为肺腺癌、临床分期为局部晚期的患者56例,其中26例应用CIK细胞联合化疗方案作为试验组,同期临床特点相近的30例作为对照组,单纯应用化疗方案,治疗结束1周期后评价两组不良反应情况。结果试验组患者骨髓抑制、恶心呕吐、肌肉酸痛等不良反应发生率均低于单纯化疗组,而发热率高于对照组,差异有统计学意义（P〈0.05）。结论 CIK细胞联合放疗可减少肺腺癌化疗所致的不良反应。

Objective To observe the clinical efficacy of cytokine-induced killer cells（CIK cells） on the adverse reactions of lung adenocarcinoma caused by chemotherapy. Methods Collected the information of 56 patients with lung adenocarcinoma from October 2011 to October 2013, CIK cells combined with chemotherapy used in 26 cases as test group（n=26）, chemotherapy used in 30 cases as the control group（n=30）. After completion of one cycle, adverse reactions were calculated in two groups. Results Of the test group, adverse reactions such as aches and pains in the mus cles, nausea and vomiting, bone marrow depression were less than that in the control group. Compared with the control group, the test group had a greater incidence of fever, with statistical significance（P〈0.05）. Conclusion CIK cells can reduce the incidence of adverse reactions of lung adenocarcinoma caused by chemotherapy.