摘要
目的探讨DWI评价非小细胞肺癌患者化疗效果的临床价值。方法回顾性分析中晚期非小细胞肺癌患者46例的临床资料,分别在化疗前、后行常规MRI平扫和DWI检测,测量化疗前后ADC值。结果化疗前DWI表现为高信号,ADC以蓝、绿、黄色为主。化疗后病灶在DWI上呈高信号,ADC图以红、黄绿色为主。化疗后ADC值显著升高,化疗后1周显著高于治疗前,化疗后2周显著高于治疗前(P均<0.01)。ADC变化率与长径变化率相关性分析结果显示,r=0.775,P<0.01。化疗后PR组患者ADC值显著升高,而SD组变化不明显,三组间化疗后比较,差异显著(P<0.01)。结论测量化疗前后ADC值可以用于化疗疗效的评估。
Objective To discuss clinical significance of DWI in assessment of clinical efficacy of chemotherapy for NSCLC. Methods Clinical data of 46 cases with NSCLC treated by chemotherapy were retrospectively analyzed. All cases were detected by MRI and DWI before and after chemotherapy, and ADC was detected. Results DWI showed high signal, and ADC showed blue, green and yellow before chemotherapy, and DWI showed high signal, and ADC showed red and yellow grean after chemotherapy. ADC increased apparently at 1 week and 2 weeks after chemotherapy compared before chemotherapy（P all0.01）. ADC rate of change was related to major axis rate of change（r=0.775,P〈0.01）. After chemotherapy, ADC of PR group increased mostly, SD group showed no significantly increased, which showed significant difference in three groups（P〈0.01）. Conclusion ADC of before and after chemotherapy can be used in curative effect evaluation chemotherapy.
出处
《中国现代医生》
2015年第6期84-86,90,F0003,共5页
China Modern Doctor
基金
浙江省自然科学基金(LY13H160028)
