药物联合心理与行为干预在宫颈高危型HPV感染中的应用研究

Effect of drug administration combined with psychological and behavioral intervention in management of cervical high-risk HPV infection

目的探讨药物（重组人干扰素α-2b阴道泡腾胶囊,辛复宁）联合心理与行为干预在宫颈单纯性、高危型HPV感染中的治疗效果。方法回顾性分析2007年1月-2013年10月间在我院采用HC2技术确诊为单纯性、宫颈高危型HPV感染的妇女共1 625例,随机分为研究组1：药物联合心理与行为干预。研究组2：心理与行为干预。对照组1：仅实施心理干预。对照组2：仅实施行为干预。分别在第3、6、12、18个月检测HPV。结果四组患者干预前病毒载量均无显著差异。但在第6个月,与各自前值相比,研究组1的HPV病毒载量与转阴率均出现显著下降（P〈0.01）,其余三组均未出现统计学差异的下降（P〉0.05）。至第12、18个月,四组均出现显著下降（P〈0.01）,但研究组1最为显著。结论推荐药物联合心理与行为干预治疗此类患者。

Objective To investigate therapeutic effect of Xinfuning（recombinant human α-2b interferon capsule for vaginal foams） combined with psychological and behavioral interventions in management of cervical high-risk HPV infection. Methods A total of 1625 cases which were confirmed with cervicalhigh-risk HPV infection as determined by HC2 technology during January 2007 to October 2013 in our hospital, were retrospectively included and randomly divided into study group 1： drug combined with psychology and behavior intervention. Study group 2： psychological and behavioral interventions. Control group 1： psychological intervention. Control group 2： behavioral intervention. Then,HPV was repeatedly determined at the time of 3, 6, 12, 18 months. Results There was no significant difference in initial viral loading among four groups. At 6 months, when compared with initial values respectively, in viral loading and negative conversion rate of study group 1 demonstrated significantly declined（both P〈0.01）, there were no statistically difference in the remaining three groups（all P〉0.05）. While at 12, 18 months, four groups showed significantly declining（all P〈0.01）, with sharpest decrease in study group 1. Conclusion Drug in combination with psychotherapy and behavior intervention can be recommended for simple, high-risk HPV cervical infection.