复合磷脂脂质体的研究进展

Composite phospholipids liposomes:research advances

脂质体是药剂学中的一类常规释药系统,可以用作难溶性药物的给药剂型,提高其生物利用度。但以往的普通脂质体存在包封率低、不稳定、长期贮存时药物易产生泄漏等问题,导致脂质体制剂产品研发受到一定限制。近年来,一种新型脂质体——复合磷脂脂质体开发出来。同传统脂质体相比,复合磷脂脂质体具有包封率和载药量较高、稳定性较好、长期贮存时药物不产生泄漏等优点,具有较好应用前景。本文主要介绍了复合磷脂脂质体的组成、结构、制备方法、作用特点以及近年在药剂学中的应用进展。

Liposomes are a kind of common drug delivery system in pharmaceutics. They can be used as the dosage form of water insoluble drugs to improve their bioavailability. However,these traditional liposomes have some disadvantages such as low encapsulation efficiency,instability and drug leakage in a long term of storage,which have limited the development of dosage form products based on liposomes. Recently,a novel kind of liposomes,namely composite phospholipids liposomes,has been devel-oped.Compared to traditional liposomes,composite phospholipids liposomes have a very promisingly application prospect due to their advantages including higher encapsulation efficiency and drug-loading efficiency,good stability and no drug leakage. This article re-viewes the research progress in the composite phospholipids liposomes,including their composition,structure,preparation method,function property and recent application in pharmaceutics.