HIV/HCV合并感染的相互影响及抗病毒治疗研究进展

Research progress of interactions between HIV and HCV and antiviral therapy in co-infected patients

HIV和HCV具有相似的传播途径,主要为输血/血制品、性接触、母婴垂直及静脉注射吸毒等,因此HIV/HCV合并感染率高。HIV和HCV在体内有复杂的相互作用,使合并感染者的病程变化多样,治疗难度加大。现将HIV/HCV合并感染后病毒间相互作用机制及临床抗病毒治疗的研究进展综述如下。

HIV and HCV frequently coexist because of their similar routes of transmission. Both viruses are mainly transmitted by exposure to contaminated blood or blood products, sexual contact, mother-to-child transmission and intravenous drug use. HIV/ HCV co-infection rate is high. There are complex interations of HIV with HCV and multiple disease courses in the co-infected patients. So they are more difficult to be treated. The authors describe the progress of the interactions of HIV and HCV and antiretroviral treatment in HIV/HCV co-infected patients.