斑马鱼在神经遗传疾病研究中的应用

Application of Zebra Fish in the Studies of Neurological Genetic Diseases

斑马鱼是最常用的神经遗传学模式生物之一,拥有体积小、性成熟周期短、体外受精、胚胎通体透明等优点。斑马鱼的基因组测序已经完成,研究相关的细胞标记技术、组织移植技术、转基因技术、基因活性抑制技术等均已成熟,在神经发育和神经功能的研究、构建人类遗传性疾病模型等多方面均展现了广阔前景。对斑马鱼在神经遗传性疾病研究中的应用进行综述。

The zebra fish （daniorerio） is a popular model organism, which has advantages like small size, short period of sexual maturation, in vitro fertilization, and transparent embryos. Genome sequencing of zebra fish has been completed. Techniques such as cell markers, tissue transplantation, transgene, gene activity inhibition have become matured. Zebra fish shows bright prospects in studying neural developments and neural functions, and constructing human genetic diseases models. Techniques to work with zebra fish and applications of zebra fish in the study of neurological genetic disease were reviewed.