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野生型胃肠道间质瘤的研究进展 被引量:5

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摘要 胃肠道间质瘤(GIST)是消化道最常见的间叶源性肿瘤,其发病率逐年递增[1].约80%的GIST有KIT突变,8%~10%的GIST有PDGFRA突变,KIT和PDGFRA均属于酪氨酸激酶受体家族,这些突变可在缺少自然配体的状态下导致激酶持续性激活.目前已证实具有KIT和PDGFRA基因突变的GIST,对酪氨酸激酶抑制剂分子靶向治疗有效.
出处 《中华病理学杂志》 CAS CSCD 北大核心 2015年第1期69-72,共4页 Chinese Journal of Pathology
基金 国家自然科学基金(81171391,81101933) 迈新病理基金(m1203)
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参考文献36

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同被引文献31

  • 1Rong Cai,Gang Ren,Deng-Bin Wang.Synchronous adenocarcinoma and gastrointestinal stromal tumors in the stomach[J].World Journal of Gastroenterology,2013,19(20):3117-3123. 被引量:3
  • 2李桂梅,张佃乾,潘素梅,殷正进.胃癌/食道癌合并胃肠间质瘤4例报道[J].临床肿瘤学杂志,2006,11(11):879-880. 被引量:6
  • 3Derya Gumurdulu,Seyda Erdogan,Fazilet Kayaselcuk,Gulsah Seydaoglu,Cem K Parsak,Orhan Demircan,Ilhan Tuncer.Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters[J].World Journal of Gastroenterology,2007,13(3):426-431. 被引量:21
  • 4中国胃肠道间质瘤病理共识意见[J].中华病理学杂志,2007,36(10):704-707. 被引量:109
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