期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

野生型胃肠道间质瘤的研究进展 被引量：5

原文传递
导出
摘要 胃肠道间质瘤（GIST）是消化道最常见的间叶源性肿瘤,其发病率逐年递增[1].约80％的GIST有KIT突变,8％～10％的GIST有PDGFRA突变,KIT和PDGFRA均属于酪氨酸激酶受体家族,这些突变可在缺少自然配体的状态下导致激酶持续性激活.目前已证实具有KIT和PDGFRA基因突变的GIST,对酪氨酸激酶抑制剂分子靶向治疗有效.
作者 时姗姗 饶秋 周晓军
机构地区 南京军区南京总医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2015年第1期69-72,共4页 Chinese Journal of Pathology
基金 国家自然科学基金（81171391,81101933） 迈新病理基金（m1203）
关键词 胃肠道间质瘤 酪氨酸激酶抑制剂 野生型 PDGFRA 基因突变 间叶源性肿瘤 GIST 分子靶向治疗
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献36

  • 1Nilsson B, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumor: the incidence, prevalence, clinical course, and prognostication in the prcimatinib mesylate era-a population-based study in western Sweden [ J ]. Cancer, 2005, 103(4): 821-829.
  • 2Agaimy A, Wunsch PH, Hofstaedter F, et al. Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations [ J ] . Am J Surg Pathol, 2007, 31(1 ) :113-120.
  • 3Rossi S, Gasparotto D, Toffolatti L, et al. Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GIST) of small size[J]. Am J Surg. Pathol, 2010, 34 (10) : 1480-1491.
  • 4Pauwels P, Debiec-Rychter M, Stul M, et al. Changing phenotype of gastrointestinalstromal tumours under imatinib mesylate treatment: a potential diagnostic pitfall [ J ]. Histopathology, 2005, 47 ( 1 ) :41-47.
  • 5Antonescu CR, Romeo S, Zhang L, et al. Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy[J]. Am J Surg Pathol, 2013, 37(3) :385-392.
  • 6Agaram NP, Wong GC, Guo T, et al. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors[ J]. Genes Chromosom Cancer, 2008, 47 (10) : 853-859.
  • 7Liegl B, Homiek JL, Antonescu CR, et al. Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression [ J]. Am J Surg Pathol, 2009, 33 (2) : 218- 226.
  • 8Huizinga JD, Thuneberg L, Kluppel M, et al. W/kit gene required for interstitial ceils of Cajal and for intestinal pacemaker activity[J]. Nature, 1995, 373(6512): 347-349.
  • 9Chi P, Chen Y, Zhang L, et al. ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours [ J ]. Nature, 2010, 467(7317) :849-853.
  • 10Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors [ J ]. Science, 1998, 279(5350) :577-580.

同被引文献31

  • 1Rong Cai,Gang Ren,Deng-Bin Wang.Synchronous adenocarcinoma and gastrointestinal stromal tumors in the stomach[J].World Journal of Gastroenterology,2013,19(20):3117-3123. 被引量：3
  • 2李桂梅,张佃乾,潘素梅,殷正进.胃癌/食道癌合并胃肠间质瘤4例报道[J].临床肿瘤学杂志,2006,11(11):879-880. 被引量：6
  • 3Derya Gumurdulu,Seyda Erdogan,Fazilet Kayaselcuk,Gulsah Seydaoglu,Cem K Parsak,Orhan Demircan,Ilhan Tuncer.Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters[J].World Journal of Gastroenterology,2007,13(3):426-431. 被引量：21
  • 4中国胃肠道间质瘤病理共识意见[J].中华病理学杂志,2007,36(10):704-707. 被引量：109
  • 5Miettinen M, Wang ZF, Sarlomo-Rikala M, et al. Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age [ J ]. Am J Surg Pathol, 2011,35( 11 ) :1712-1721.
  • 6Barletta JA, Homick JL. Succinate dehydrogenase-deficient tumors: diagnostic advances and clinical implications [ J ]. Adv Anat Pathul, 2012, 19(4) :193-203.
  • 7Gill AJ. Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia[J]. Pathology, 2012, 44(4):285-292.
  • 8Williamson SR, Eble JN, Amin MB, et al. Succinate dehydrogenase-deficient renal cell carcinoma : detailed characterization of 11 tumors defining a unique subtype of renal cell careinoma[ J]. Med Pathol, 2015, 28( 1 ) :80-94.
  • 9Gill AJ, Toon CW, Clarkson A, et al. Succinate dehydregenase deficiency is rare in pituitary adenomas [ J ]. Am J Surg Pathol, 2014, 38(4) :560-566.
  • 10Gill A J, Chou A, Vilain R, et al. Immunohistochemistry for SDHB divides gastrointestinal stmmal tumors (GISTs) into 2 distinct types[ J]. Am J Surg Pathol, 2010,34(5 ) :636-644.

引证文献5

二级引证文献14

中华病理学杂志
2015年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部