铜绿假单胞菌Ⅲ型分泌系统的研究进展

Research progress of type Ⅲ secretion system in Pseudomonas aeruginosa

铜绿假单胞菌是临床常见的重要条件致病菌,具有多种毒力因子,能引起各种急慢性感染。其中最重要的毒力因子是Ⅲ型分泌系统,主动向宿主细胞靶向输送效应蛋白,引起宿主细胞的病理变化,并逃避免疫细胞的降解。研究Ⅲ型分泌系统不仅有助于明确铜绿假单胞菌的致病机制,更重要的是为临床治疗及新药研发提供新思路。

Pseudomonas aeruginosais an important conditioned pathogen with a variety of virulence factors in the clinic.It can cause a wide variety of acute and chronic infections.One of the most important of virulence factors is the type III secretion system（T3SS）that translocate effector proteins from the bacterium into the host cells to causes the pathological changes of host cells,and to escape degradation of immune cells.Research T3 SS could help to clarify the pathogenesis of Pseudomonas aeruginosa,and more importantly,to provide new ideals for clinical treatment and drug development.