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KCNJ11和KCNQ1基因与中国人2型糖尿病的关系 被引量：5

Association of KCNJ11 and KCNQ1 genes with type 2 diabetes mellitus in Chinese population
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摘要 目的研究KCNJ11和KCNQ1基因多态位点与中国人2型糖尿病(T2DM)的相关性。方法采用基质辅助激光解吸电离飞行时间质谱技术检测T2DM患者(A组,922例)和正常糖耐量者(B组,925例)KCNJ11基因rs5219位点及KCNQ1基因rs2237892位点的基因型和等位基因频率。结果两组间KCNJ11基因rs5219位点等位基因频率差异无统计学意义(P>0.05),而KCNQ1基因rs2237892位点等位基因频率差异有统计学意义(P<0.05)。结论 KCNQ1基因与中国人T2DM相关。 Objective To investigate the association of single nucleotide polymorphisms of KCNJ11 and KCNQ1genes with type 2diabetes mellitus（T2DM）in Chinese population.Methods The genotypes and allele frequencies of KCNJ11 gene at rs5219 site and KCNQ1 gene at rs2237892 site were detected by matrix-assisted laser desorption/ionisation time-off light mass spectroscopy in922 cases with T2DM（group A）and 925 cases with normal glucose tolerance（group B）.Results There was no significant difference in allele frequency of KCNJ11 gene at rs5219 site between groups of A and B（P〉0.05）,while the allele frequency of KCNQ1 gene at rs2237892 site in group A was obviously different from that in group B（P〈0.05）.Conclusion KCNQ1 gene is associated with T2 DM in Chinese population.
作者 沈琴 李文亚 胡兴坡 邓雁北
机构地区 上海交通大学苏州九龙医院内分泌病科
出处 《江苏医药》 CAS 2015年第2期157-159,共3页 Jiangsu Medical Journal
关键词 KCNJ11基因 KCNQ1基因 单核苷酸多态性 2型糖尿病 KCNJ11gene KCNQ1gene Single nucleotide polymorphism Type 2diabetes mellitus
分类号 R587 [医药卫生—内分泌]
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参考文献16

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同被引文献48

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江苏医药
2015年 第2期

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