MicroRNA对T细胞发育调控作用的研究

Advances in Relationship between MicroRNA and Development of T Lymphocyte

Micro RNA（mi RNA）是一类非编码小分子RNA,长约21～25个核苷酸,可以靶向结合特定的信使RNA（m RNA）,能够在转录后水平上调节m RNA的翻译进而调控基因的表达。mi RNA的调控功能涉及多种生物学过程,与免疫疾病密切相关。近年来发现,mi RNA可以通过靶向免疫系统中的关键转导信号分子,从而在多个环节上参与免疫细胞的产生、发育以及增殖过程。该文对mi RNA与T细胞的发育关系进行简要概述。

MicroRNA （miRNA） is a class of small non-coding RNA molecules, 21～25 nucleotides long. miR- NA can target the certain mRNA and modulate the gene expression at the post-transcriptional level. They play important roles in diverse biological processes including immune. Recent studies showed that miRNA could regulate the develop- ment and activation of immunocytes by targeting the critical signals of the pathways. In this review, we summarized some recent research progresses of miRNA involved in the development, differentiation and function of T cells.