Filaggrin基因及聚角蛋白微丝蛋白的研究现状

The Actuality of Filaggrin Gene and Filaggrin

Filaggrin基因(FLG基因),位于人类染色体1q21.3,是一种与细胞分化密切相关的基因。Filaggrin基因翻译表达为聚角蛋白微丝蛋白前体(Profilaggrin),后者通过Kallikrein5(KLK5)的作用,生成聚角蛋白微丝蛋白(Filaggrin),维持表皮屏障的完整性。而Filaggrin被Caspase-14分解成小分子物质,继续发挥着保水、防紫外线的作用。FLG基因是易于突变的基因,其突变或者缺失致使Filaggrin生成减少,这正是一些疾病发生的根本原因。该文就FLG基因的调控及Filaggrin与相关疾病的发生发展的关系作一综述。

Filaggrin gene （FLG）, located at human chromosome lq21.3, is closely related to cell differ- entiation. FLG can translate to Profilaggrin. Profilaggrin is degraded by Kallikrein5 （KLK5） to Filaggrin, which is correlated with the integrity of epidermal barrier. Filaggrin is broken down by Caspase-14 into small molecular substances, which can play the role of waterproof and ultraviolet rays （UV） protection. Mutation or deficiency of FLG results in decreasing production of Filaggrin, which is the basic causes of some diseases. This article focuses on reviewing the regulation of FLG and the relationship between Filaggrin and related diseases.