摘要
微小RNA(micro RNA,mi RNA)是一类非编码单链小分子RNA,参与调控细胞增殖、分化、凋亡及迁移等多种生理过程。最新研究发现,mi RNA在子宫肌瘤发生发展中的细胞转化、组织重构、血管生成及炎症反应等方面均起着重要调控作用。这提示,mi RNA不但可以作为探索子宫肌瘤发病机制的新途径,而且可能成为子宫肌瘤诊断、治疗和预后判断的新靶点。该文就近年来mi RNA在子宫肌瘤发病机制研究中的现状进行综述。
MicroRNA (miRNA) is a small non-coding single strand RNA molecule. The functions of miR- NA are broadly involved in cell proliferation, differentiation, apoptosis and migration. Recent findings indicated that miRNA also played an important role in the pathogenesis of human uterine leiomyomas, which includes cell transformation, tissue resembling, angiogenesis and inflammation. It may be applied as not only a new way to ex- plore the pathogenesis of human uterine leiomyomas, but also a new target for disease diagnosis, therapy and prog- nosis. In this review, the most newly progress of miRNA in the pathogenesis of human uterine leiomyomas will be summarized.
出处
《中国细胞生物学学报》
CAS
CSCD
2015年第1期137-142,共6页
Chinese Journal of Cell Biology
基金
长海医院"1255"学科建设计划(批准号:CH125510105)
上海卫生系统重大疾病联合攻关项目(批准号:2013ZYJB0201)资助的课题~~
关键词
微小RNA
子宫肌瘤
发病机制
诊断
miRNA
human uterine leiomyomas
disease mechanism
diagnosis