骨髓微环境对造血干细胞静息的调节机制

Regulation Mechanism of Bone Marrow Niche on Hematopoietic Stem Cell Quiescence

自我更新、多向分化和静息状态是造血干细胞的重要特征,其中静息状态的维持是维持造血干细胞数量及造血干细胞池稳定的重要机制。骨髓微环境是造血干细胞定居的场所,是维持造血干细胞静息必要的土壤,尤其是成骨细胞微环境可通过多种跨膜分子信号通路、黏附分子等调节造血干细胞的静息。造血干细胞静息关系到造血干细胞自我更新的平衡,其失衡与白血病的发生及白血病干细胞的干性维持相关。该文通过总结近几年最新研究进展并结合作者实验室的研究成果,对介导骨髓微环境调节造血干细胞静息的主要分子机制作一综述。

Hematopoietic stem cell （HSC） is characterized by its potentiality in self-renewal, multipotential differentiation and quiescence. Quiescent state is more important to maintain the number of HSC and the stability of HSC pool. HSC resides in bone marrow niche, which provides necessary soil to maintain HSC quiescence. Bone marrow niche, especially osteoblast niche, regulates HSC quiescence through a variety of transmembrane molecules, signaling pathways and adhesion molecules. Quiescence of HSC is critical for HSC＇ self-renewal. Imbalance between self-renewal and quiescence may be associated with leukemogenesis and even be essential for leukemia stem cells＇ stemness. In this review, based on the recent research progress and the results of our study, we briefly reviewed the current advances of the quiescence regulators in the bone marrow niche for the HSC.