摘要
The development of multidrug resistance （MDR） has become an increasingly serious problem in cancer therapy, making the long-term survival of patients with MDR- associated cancers extremely challenging. The cell-membrane overexpression of P-glycoprotein （P-gp）, which can actively efflux various anticancer drugs from the cell, is a major mechanism of MDR. Nuclear-uptake nanodrug delivery systems, which enable intranuclear release of anti- cancer drugs, are expected to address this challenge by bypassing P-gp.
The development of multidrug resistance(MDR)has become an increasingly serious problem in cancer therapy,making the long-term survival of patients with MDRassociated cancers extremely challenging.The cell-membrane overexpression of P-glycoprotein(P-gp),which can actively efflux various anticancer drugs from the cell,is a major mechanism of MDR.Nuclear-uptake nanodrug delivery systems,which enable intranuclear release of anticancer drugs,are expected to address this challenge by by-
