益智提取物对肾阳虚大鼠的作用

Effect of Alpinia Oxyphylla Fructus Extract on Kidney-Yang Deficiency Syndrome Rats

目的研究益智对肾阳虚大鼠的作用。方法腹腔注射氢化可的松造成大鼠肾阳虚模型,分别给予益智95%乙醇提物、90%乙醇洗脱物、50%乙醇洗脱物经口给药10 d进行干预,观察大鼠尿量、尿中Na+、K+、Cl-浓度,血浆尿素氮(BUN)、肌酐(Cr)、三碘甲状腺原氨酸(T3)和四碘甲状腺原氨酸(T4)含量。结果益智提取物对肾阳虚大鼠尿量增多无显著影响(P>0.05),可降低血浆Cr(P<0.01)、升高T4水平(P<0.01)。结论益智可能通过调节血浆Cr、T4水平发挥暖肾作用。

OBJECTIVE To study the effect of Alpinia oxyphylla fructus extract on kidney-yang deficiency syndrome rats.METHODS Rats were injected intraperitoneally hydrocortisone to simulate kidney-yang deficiency syndrome and administered orally Alpinia oxyphylla fructus 95% enthanol extract,90% enthanol eluate,50% enthanol eluate respectively once daily. Urine volume were measured; and concentration of Na＋,K＋and Cl-in urine of rats were detected; BUN,Cr,T3 and T4 in plasma were detected.RESULTS Alpinia oxyphylla fructus extract had no influence on urine volume（ P0.05）. However it could reduce（ P0.01） Cr and increase T4（ P0.01） in plasma. CONCLUSION Alpinia oxyphylla fructus＇ s effect on kidney-yang deficiency maybe through adjust Cr,T4 level in plasma.