榄香烯注射液在肺癌术后化疗中的作用及化疗后毒副反应处理

The effect of elemene injection in lung cancer chemotherapy and the toxi-city treatment after chemotherapy

目的观察榄香烯注射液在肺癌术后化疗中的辅助治疗作用,以及观察肺癌术后化疗药物的毒副反应。方法 70例肺癌患者依据治疗方式不同分为对照组35例通过静脉滴注顺铂注射液＋注射用吉西他滨化疗,治疗组35例在对照组的基础上加静脉滴注榄香烯注射液的方案,采用病例对照的研究方法,比较治疗组与对照组的化疗疗效和毒副反应,总结化疗药物毒副反应的临床处理经验。结果治疗组比对照组辅助化疗的疗效更好,治疗组总缓解率为60.0%,对照组总缓解率为48.6%,差异有统计学意义（P〈0.05）;治疗组比较对照组,化疗的毒副反应更轻,差异有显著性（P〈0.05）;并且通过得当的处理,70例肺癌患者均完成4~6个周期化疗。结论榄香烯注射液可以提高肺癌术后化疗的疗效,减轻化疗的毒副反应;肺癌术后化疗患者毒副反应处理得当可减轻患者的痛苦,保证患者按化疗计划顺利进行。

Objective To observe the effect of elemene injection of adjuvant therapy after lung cancer chemotherapy and the toxicity of postoperative lung cancer chemotherapy drugs. Methods Seventy lung cancer patients were divided into the control group and the treatment group arranged by different treatment. 35 patients in control group received the chemotherapy of intravenous infusion of cisplatin injection and gemcitabine injection while 35 patients in treatment group were treated with the same chemotherapy combined with elemene injection. The chemotherapy and toxicity of elemene injection were compared in the treatment group and the control group according to the research method of casecontrol, and the clinical experience in handling of chemotherapy toxicity were summarized. All statistical data were analyzed by test method. Results The efficacy of adjuvant chemotherapy was better in treatment group than control group. The total response rate of treatment group was 60.0% while the overall re sponse rate of the control group was48.6%, the difference was statistically significant（P〈0.05）; the toxicity of chemotherapy was lighter in treatment group than control group, the difference was statistically significant（P〈0.05）. 4-6 cycles of chemotherapy were completed in70 cases of lung cancer patients with proper handling. Conclusion Elemene injection can improve the efficacy of chemotherapy for lung cancer surgery and reduce the toxicity of chemotherapy. Toxicity in lung cancer patients after chemotherapy was handled properly, which can alleviate the suffering of patients and ensure that patients were planned to the smooth progress of chemotherapy.