摘要
目的 探讨中国人软组织肉瘤(soft tissue sarcoma,STS)的临床特点、发病趋势及病理亚型,为制定软组织肉瘤的规范化治疗指南提供依据。方法 对北京大学肿瘤医院骨与软组织肿瘤科在2007年7月至2013年11月间收治的687例软组织肉瘤患者的临床及病理资料进行回顾性研究。结果收治的软组织肉瘤患者以肢体占绝大多数,其中男性430例,女性257例。男女发病比例约1.67∶1。发病年龄在4~84岁之间,平均发病年龄45.6岁,中位发病年龄45岁。常见的软组织肉瘤包括恶性纤维组织细胞瘤/高级别多形性未分化肉瘤(20.52%),脂肪肉瘤(18.63%),皮肤隆突性纤维肉瘤(14.26%),滑膜肉瘤(11.35%),纤维肉瘤(8.01%)等。STS好发部位依次为下肢、躯干、上肢、肩部、胸壁、臀部、腹壁、头颈等处。结论 STS临床及病理表现复杂,治疗效果差。而受发病率低等因素的制约,国内对STS的大样本量研究较少,应尽快开展多中心大样本的研究。
Objective This study is to discuss the clinical characteristics,incidence trend and pathological subtypes of Chinese sarcoma patients,and provide evidence to the standard treatment guidelines of the soft tissue sarcomas. Methods 687 STS patients were treated in department of bone and soft tissue tumor of Peking University Cancer Hospital from July,2007 to November,2013. The clinical and pathological data were under retrospective analysis. Results Most patients were of extremity soft tissue sarcomas. There were 430 male,257 female; the male-female ratio is 1. 67 ∶ 1. The onset age is between 4-84 years,the average onset age is45. 6,the mean onset age is 45. The more common sarcoma subtypes include malignant fibrous histiocytoma( MFH) /high level pleomorphic undifferentiated sarcoma( 20. 52%),liposarcoma( 18. 63%),dermatofibrosarcoma protuberans( 14. 26%),synovial sarcoma( 11. 35%),fibrosarcoma( 8. 01%). The predilection sites of STS are lower limbs,trunk,upper limbs,shoulders,chest wall,hips,abdominal wall,head and neck.Conclusions STS is of complex clinical and pathological performance,with poor treatment outcome. Because of the very low morbidity,there is little large sample study of STS in China,so the multi-center large sample study should be given consideration as soon as possible.
出处
《中国肿瘤外科杂志》
CAS
2015年第1期6-8,13,共4页
Chinese Journal of Surgical Oncology
关键词
软组织肉瘤
流行病学
病理学
soft tissue sarcoma
epidemiology
pathology