二甲双胍治疗代谢综合征伴肾脏损害的治疗分析

Treatment analysis of metformin for metabolic syndrome complicated with renal damage

目的分析二甲双胍治疗代谢综合征(MS)伴肾脏损害的临床疗效。方法 50例代谢综合征伴肾脏损害患者,随机分为两组,每组25例。对照组给予厄贝沙坦治疗,观察组在对照组的基础上加用二甲双胍治疗,比较两组患者的临床疗效和不良反应。结果治疗后观察组蛋白尿、三酰甘油(TG)水平、尿白蛋白排泄率(UAER)明显低于对照组(P<0.05),两组体质量指数(BMI)、空腹血搪(FPG)均无明显改变,差异无统计学意义(P>0.05);两组患者均未出现低血压、低血糖、高血钾、肾功异常等不良反应。结论二甲双胍治疗MS可有效改善患者临床症状,不良反应少,值得推广应用。

Objective To analyze the clinical effect of metformin in treatment of metabolic syndrome（MS） complicated with kidney damage. Methods A total of 50 patients of metabolic syndrome complicated with kidney damage were randomly divided into two groups with 25 cases in each group. The control group received irbesartan for treatment, and the observation group received additional metformin on the basis of control group. Clinical effects and adverse reactions of the two groups were compared. Results After the treatment, the observation group had lower levels of proteinuria, triacylglycerol（TG）, and urinary albumin excretion rate（UAER） than the control group（P〈0.05）. There were no obvious changes in body mass index（BMI） and fasting plasma glucose（FPG） in the two groups, and the difference had no statistical significance（P〉0.05）. Both groups had no adverse reactions as hypotension, hypoglycemia, hyperkalemia, and abnormal renal function. Conclusion Metformin in the treatment of MS can significantly improve patients＇ clinical symptoms with few adverse reactions. It is worthy of promotion and application.