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脯氨酰寡肽酶的肝内生物学功能研究进展 被引量：5

Biological function of prolyl oligopeptidase in the liver
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摘要 脯氨酰寡肽酶(prolyl oligopeptidase,POP)体内分布广泛,肝内活性较高。POP通过直接或间接作用,影响Kupffer细胞等炎性细胞、肝细胞和肝星状细胞功能,调控肝内炎症、肝细胞增殖和细胞外基质(extracellular matrix,ECM)沉积,在肝脏损伤修复中发挥重要作用,可能成为慢性肝损伤修复机制研究及治疗的新切入点。本文就POP的肝内生物学功能作一概述。 Prolyl oligopeptidase （ POP） is widely distribute in the body and highly activity in the liver. POP affects the functions of inflammatory cells such as Kupffer cells, hepatic stellate cells and hepatocytes in a direct or indirect way, regulates inflammation, extracellular matrix （ ECM） deposition and hepatocyte proliferation, and plays an impor-tant role in liver repair after chronic injury. POP may become a promising target for mechanical study and therapy of pathological liver repair after chronic liver injury. This paper reviews the recent advance in biological function of POP in the liver.
作者 周达 陈源文 范建高
机构地区 上海交通大学医学院附属新华医院消化内科
出处 《胃肠病学和肝病学杂志》 CAS 2015年第1期12-14,共3页 Chinese Journal of Gastroenterology and Hepatology
基金 国家自然科学基金(81170410 81260081) 上海市卫生系统优秀青年人才培养计划(XYQ2011010) 上海市科委浦江人才计划(10PJ1407600)
关键词 脯氨酰寡肽酶 肝脏 肝细胞 炎症 纤维化 Prolyl oligopeptidase Liver Hepatocyte Inflammation Fibrosis
分类号 R574.62 [医药卫生—消化系统]
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参考文献19

  • 1Peltonen I, Myohanen TT, Mannisti:i PT. Association of prolyl oli?gopeptidase with conventional neurotransmitters in the brain[I]. CNS Neurol Disord Drug Targets, 2011,10(3): 311-318.
  • 2Tenorio-LarangaJ, VenalainenJI, Mannisto PT, et al. Characteriza?tion of membrane-bound prolyl endopeptidase from brain[J]. FEBSJ, 2008, 275(17): 4415-4427.
  • 3Mylihanen TT, VenalainenJI, Garcia-HorsmanJA, et al. Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripher?al tissues[I]. Histochem Cell Bioi, 2008,130(5): 993-1003.
  • 4Agirregoitia N, GilJ, Ruiz F, et al. Effect of aging on rat tissue pepti?dase activities[J].J Gerontol A Bioi Sci Med Sci, 2003, 58 ( 9) : B792-B797.
  • 5Yamakawa N, Shimeno H, Soeda 5, et al. Inhibition of proline endo?peptidase activity by acyl-coenzyme A esters[J]. Biochim Biophys Acta,1990,1037(3): 302-306.
  • 6Soeda S, Yamakawa N, Sbimeno H, et al. Effects of polyamines on proline endopeptidase activity in rat brain[J].J Neurochem,1986, 46 (4) :1304-1307.
  • 7Kanaeaki K, Nagai T, Nitta K, et al. N-acetyl-seryl-aspartyl-Iysyl-pro?line: a valuable endogenous anti-fibrotic peptide for combating kidney fibrosis in diabetes[J]. Front Pharmacol, 2014, 5: 70.
  • 8Nozaki Y, Sato N, lida T, et al. Prolyl endopeptidase purified from granulomatous inflammation in mice[J].J Cell Biocbem,1992, 49 (3) : 296-303.
  • 9Chen YW, Liu BW, Zhang YJ, et al. Preservation of basal AcSDKP attenuates carbon tetrachloride-induced fibrosis in the rat liver[J].J Hepatol, 2010, 53(3): 528-536.
  • 10陈源文,董国芳,徐雷鸣,刘博伟,陈颖伟,李定国.内源性AcSDKP及其前体胸腺素β4在四氯化碳致肝纤维化发生早期的变化[J].胃肠病学和肝病学杂志,2010,19(1):6-9. 被引量：5

二级参考文献11

  • 1Dainiak N. Negative regulators of hematopoietic stem cells and progeni- tors [J]. Exp Hematol, 1992, 20(10): 1154-1155.
  • 2Rousseau-Plasse A, Lenfant M, Potier P. Catabolism of the hemoregulatory peptide N-Acetyl-Ser-Asp-Lys-Pro: a new insight into the physiological role of the angiotensin-I-converting enzyme N-active site [J]. Bioorg Med Chem, 1996, 4(7) : 1113-1119.
  • 3Peng H, Carretero OA, Brigstock DR, et al. AcSDKP reverses cardiac fibrosis in rats with renovascular hypertension [ J ]. Hypertension, 2003, 42(6) : 1164-1170.
  • 4Rossdeutsch A, Smart N, Riley PR. Thymosin beta4 and Ac-SDKP: tools to mend a broken heart [J]. J Mol Med, 2008, 86(1) : 29-35.
  • 5Pokharel S, Rasoul S, Roks AJ, et al. N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts [ J]. Hypertension, 2002, 40(2) : 155-161.
  • 6Rhaleb NE, Peng H, Harding P, et al. Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts [J]. Hypertension, 2001, 37(3): 827-832.
  • 7Sharma U, Rhaleb NE, Pokharel S, et al. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage [ J]. Am J Physiol Heart Circ Physiol, 2008,294 (3) :H1226-1232.
  • 8Rasoul S, Carretero OA, Peng H, et al. Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension [ J]. J Hypertens, 2004, 22(3): 593-603.
  • 9Sancho-Bru P, Bataller R, Fernandez-Varo G, et al. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury [J]. Gastroenterology, 2007, 133(6): 2019-2028.
  • 10Leung PS, Suen PM, lp SP, et al. Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response [ J ]. Regul Pept, 2003, 116 ( 1-3 ) : 61-69.

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胃肠病学和肝病学杂志
2015年 第1期

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