不同新辅助化疗方案对结直肠癌患者生存质量的前瞻性非随机观察研究

A prospective non-randomized observational study on the life quality of patients with colorectal cancer of neoadjuvant chemotherapy

目的探讨OLF和LF不同新辅助化疗方案对结直肠癌患者生存质量的影响。方法收集临沂市罗庄中心医院2009年3月-2012年12月收治的136例结直肠癌患者依据病情和意愿分组,分别采取OLF和LF新辅助化疗方案,以QLQC30生存质量核心问卷比较化疗前、手术前和手术后患者的生存质量。结果手术前,OLF组在总分、恶心呕吐和经济困难指标上与化疗前比较,差异有统计学意义(P<0.05);LF组在总分、恶心呕吐症状上与化疗前比较,差异有统计学意义(P<0.05);手术后,两组在总分、症状评分上与化疗前和手术前比较,差异有统计学意义(P<0.05);两组前手术前恶心呕吐症状、手术后社会功能、腹泻、经济困难比较,差异有统计学意义(P<0.05)。结论两种化疗方案均可以改善患者的生存质量,OLF化疗方案对患者功能和症状改善更为明显。

Objective To investigate the effect of different neoadjuvant chemotherapy （ OLF and LF） on quality of life in patients with colorectal cancer. Methods Patients with colorectal cancer were grouped according to the illness and willingness in the Luozhuang Center Hospital from Mar. 2009 to Dec. 2012 and OLF and LF were adopted respec-tively neoadjuvant chemotherapy group. The quality of life of QLQC30 core questionnaire before chemotherapy, before operation and after operation were compared. Results Before operation, the total score, the symptoms of nausea and vomiting, economic difficulties in OLF group were significant difference compared with before chemotherapy; the total score, the symptoms of nausea and vomiting were significant difference compared with before chemotheroupy （ P 〈0. 05）;after operation, the total score, symptoms score in two groups were significant difference compared with before chemotherapy and operation （P〈0. 05）. The symptoms of nausea and vomiting before operation, the social function, diarrhea , economic difficulties after operation were significant difference between two groups （ P〈0 . 05 ） . Conclusion Two chemotherapy can improve the quality of life of patients, while OLF chemotherapy is more obvious in functional and symptom improvement for patients.