摘要
本文考察了氧化石墨烯(graphene oxide,GO)固化挥发油的特性。分别应用GO吸附丁香油与莪术油,以丁香酚和莪术醇收率为指标,优选GO用量;采用差示扫描量热法和扫描电镜法对固化粉末进行物相表征;考察GO对挥发油中有效成分体外溶出和受热稳定性的影响。结果表明,GO与挥发油最佳固化比例为1∶1,挥发油被固化后,对有效成分的体外溶出速率基本无影响,且受热稳定性得到提高。GO固化中药挥发油具有一定的应用前景,值得进一步研究。
To evaluate the properties of solidifying volatile oil with graphene oxide, clove oil and zedoary turmeric oil were solidified by graphene oxide. The amount of graphene oxide was optimized with the eugenol yield and curcumol yield as criteria. Curing powder was characterized by differential scanning calorimetry（DSC） and scanning electron microscopy（SEM）. The effects of graphene oxide on dissolution in vitro and thermal stability of active components were studied. The optimum solidification ratio of graphene oxide to volatile oil was 1∶1. Dissolution rate of active components had rare influence while their thermal stability improved after volatile oil was solidified. Solidifying herbal volatile oil with graphene oxide deserves further study.
出处
《药学学报》
CAS
CSCD
北大核心
2015年第2期222-226,共5页
Acta Pharmaceutica Sinica
基金
江苏省社会发展科技支撑计划(BE2010756)
江苏省中医药科技项目(LZ11065)
关键词
挥发油
氧化石墨烯
吸附率
表征
体外溶出度
受热稳定性
volatile oil
graphene oxide
adsorption rate
characterization
dissolution in vitro
thermal stability
