摘要
p62是一种多功能泛素结合蛋白,参与泛素蛋白酶体系统(ubiquitin-proteasome system,UPS)和自噬-溶酶体系统两种蛋白降解过程。p62作为一种信号转导途径中的支架和适配子蛋白,其分子结构中的多个功能结构域可与其它蛋白质相互作用,介导多种细胞功能,特别是在细胞的选择性自噬和细胞抗氧化反应中发挥重要作用,因而p62与许多疾病的发病机制密切相关。本文主要综述p62的结构特征及其与UPS和自噬的相互关系,旨在为相关领域的研究提供参考。
The p26, a multifunctional ubiquitin-binding protein, has been proposed to be involved in protein degradation as a compo- nent within the ubiquitin-proteasome and autophagy-lysosome systems. As a scaffolding protein with several different kinds of protein-protein interaction domains, p62 mediates various cellular functions, importantly, p62 plays a critical role in cell＇s selective autophagy and oxidative stress response, which are associated with the pathogenesis of several human diseases. In this review, we describe the structure of p62 and the mechanism of connection between p62 and ubiquitin-proteasome system/autophagy, so as to provide some perspectives on p62 research.
出处
《生理学报》
CAS
CSCD
北大核心
2015年第1期48-58,共11页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No.30771140)
the Scientific Research Project of Educational Department of Henan Province
China(No.13A310070)
关键词
P62
蛋白降解
泛素
蛋白酶体
自噬
p62
protein degradation
ubiquitin
proteasome
autophagy
