IL-18、IL-1β水平与非酒精性脂肪性肝病的关系

Study on the correlation between interleukin-18,interleukin-1β and nonalcoholic fatty liver disease

目的探讨血清炎症因子白细胞介素18(IL-18)、白细胞介素1β(IL-1β)与非酒精性脂肪性肝病(NAFLD)的关系。方法选取NAFLD患者作为NAFLD组(n=46)、正常对照者作为对照组(n=45),对被选人群进行问卷调查、体格测量、人体成分分析及肝脏超声检查。收集其体检报告。ELISA法检测血清IL-18、IL-1β。结果 NAFLD组体质指数(BMI)、内脏脂肪面积、体脂百分比、腰臀百分比、白细胞计数、中性粒细胞绝对数、淋巴细胞计数、空腹血糖、三酰甘油(TG)、极低密度脂蛋白、谷丙转氨酶、血尿酸及IL-18、IL-1β均明显高于对照组,差异有统计学意义(P<0.05)。同时,相关分析显示血清IL-18及IL-1β水平与BMI、TG均有相关性。结论在NAFLD患者血清中炎症因子IL-18、IL-1β均明显升高,IL-18、IL-1β参与的慢性炎症反应可能是NAFLD的病因之一。

Objective To investigate the relationship of the serum levels of interleukin-18（IL-18）,interleukin-1β（ IL-1β） with pathogenesis of nonalcoholic fatty liver disease（ NAFLD） . Methods 46 cases of NAFLD patients, 45 cases of normal controls were selected, questionnaire survey, physical measurement, body composition and liver ultrasound were conducted for selected population. Collect the physical examination report, serum levels of IL-18 and IL-1β were examined by ELISA. Results The body mass index （BMI）,visceral fat area,percent body fat, waist-hip ratio,white blood cell, absolute neutrophil count, absolute lymphocyte count, fasting plasma glucose, tri-glycerides（ TG） ,very low density lipoprotein,alanine transaminase and blood uric acid,serum levels of IL-18 and IL-1β were significantly higher in NAFLD group than in control group（P〈0. 05）,with statistical significance. The correlative analysis showed that the serum levels of IL-18 and IL-1β were correlated with body mass index and tri-glycerides. Conclusion Serum levels of IL-18 and IL-1β in NAFLD group are higher than those in control group, IL-18 and IL-1β participating in chronic inflammation may be one of the causes of NAFLD.