ER、PR的表达与乳腺癌患者化疗相关认知障碍的相关性研究

Correlative study of the expression of ER,PR and breast cancer patients chemotherapy-induced cognitive impairment

目的探讨雌激素受体(ER)和孕激素受体(PR)与乳腺癌患者化疗相关认知障碍(CICI)的相关性。方法 60例术后辅助化疗后乳腺癌患者作为乳腺癌组,其中ER和PR双阴性患者30例为A组、ER和PR双阳性患者30例为B组;另以年龄及教育程度相匹配的60例健康女性志愿者为对照组。分别对其进行简易精神状态量表(MMSE)和中文听觉词语学习测验(AVLT)测查。结果乳腺癌组与对照组MMSE成绩相比差异有统计学意义(t=-12.824,P<0.05);A组和B组在MMSE、即刻记忆和延迟记忆成绩方面差异均有统计学意义(t=-3.311、-3.616、-2.264,P<0.05)。结论化疗后乳腺癌患者存在不同程度的认知功能障碍,且ER和PR双阴性患者在总体认知功能及记忆方面损害较ER和PR双阳性患者显著(P<0.05),提示ER、PR的不同表达可能与乳腺癌CICI的异质性有关。

Objective To investigate the correlation between estrogen receptor （ ER） , progesterone receptor （ PR）and chemotherapy-induced cognitive impairment（ CICI） of patients with breast cancer. Methods Take 60 breast cancer patients who had received adjuvant chemotherapy after operation as breast cancer group, in which group A included 30 patients with ER and PR double negative, group B included 30 patients with ER and PR double posi-tive. In addition, we also selected 60 cases of healthy women volunteers with age and education level matched as control group. All participants were administered with mini mental state examination （ MMSE） and auditory verbal learning test （ AVLT） tasks. Results Differences of MMSE score between breast cancer group and control group were statistically significant （t= -12. 824, P〈0. 05;diifferences between group A and group B in MMSE socre, immediate memory and delay memory score were statistically significant （ t = -3. 311 , -3. 616 , -2. 264 , P 〈0. 05 ） . Conclusion Patients with breast cancer after chemotherapy exist in different extent of cognitive impair-ment , and the general cognitive function and memory damage of patients with ER and PR double negative are obvi-ous while comparing to patients with ER and PR double positive （ P〈0. 05 ） , implying that different ER and PR expression may be related to the heterogeneity of CICI in breast cancer .