乳腺癌TICⅡ、Ⅲ型曲线类型及ADC值与Ki-67相关性研究

Correlations between Ki-67 and the TIC curve type and the ADC values of patients in breast cancer

目的探讨乳腺癌MRI动态增强曲线(TIC)类型、弥散表观系数(ADC)值与免疫组化标志物Ki-67表达的相关性。方法搜集乳腺病例43例,全部行MRI动态增强扫描及弥散加权成像(DWI),测其TIC类型及其ADC值,且所有病例做病理和肿瘤指标Ki-67的免疫组化,并统计分析TICⅡ、Ⅲ型曲线类型及ADC值与Ki-67的表达是否存在相关性。结果乳腺癌ADC值越低,其Ki-67表达越高;TIC曲线类型Ⅲ型者Ki-67表达较Ⅱ型者阳性率高。结论 TIC类型及ADC值与Ki-67的表达存在一定相关性,可为临床评估乳腺癌预后提供有利依据。

Objective The aim of this study was to determine the relationships among Ki-67 and the TIC curve type and the ADC values of patients in breast cancer. Methods 43 patients who performed dynamic contrast-enhanced MRI and diffusion weighted imaging（ DWI） in preoperative phase were selected. Measuring ADC values and dy-namic enhancement curve （ TIC） type. And all of these patients had done the pathology and the tumor marker of Ki-67 . Statistical analysis was used to compare the correlations between Ki-67 and the TIC type and the ADC values. Results The lower the ADC valued, the higher the Ki-67expressed. The Ki-67 expressions in TIC curve type Ⅲ were higher than type Ⅱ. Conclusion The dynamic enhanced MRI curve type and the ADC values have a certain correlation with the expressions of Ki-67 , and can provide advantageous basis for clinical to assess the prognosis of breast cancer.