组织结构声学定量分析技术评价早期肝硬化的应用价值

The application value in early liver cirrhosis by acoustic structure quantification technology

目的探讨组织结构声学定量分析技术(ASQ)在早期肝硬化(ELC)诊断中的应用价值。方法收集60例健康志愿者(正常对照组)和40例病理诊断明确的ELC患者(ELC组)的ASQ图像,分析其肝实质的原始回波信号,记录χ2直方图及ASQ相关参数,包括红线众数、红线平均值、红线标准差、蓝线众数、蓝线平均值、蓝线标准差及蓝红曲线下面积比,对各参数绘制受试者工作特征(ROC)曲线并获得界值。结果红线众数、红线平均值、红线标准差、蓝线众数、蓝线平均值、蓝线标准差及蓝红曲线下面积比在正常对照组与ELC组间比较差异有统计学意义(P<0.01)。ROC评价显示以上参数的ROC曲线偏左上角,曲线下面积(AUC)均大于0.7,且与AUC=0.5比较差异有统计学意义(P<0.01)。其中,蓝红曲线下面积比的AUC大于0.9,其界值为0.10,对应的灵敏度和特异度分别为76%和98.2%。结论 ASQ技术是非侵入性检测ELC的新技术,其相关参数,特别是蓝红曲线下面积比在ELC的定量诊断中有一定的应用价值。

Objective To explore the application value of acoustic structure quantification （ ASQ ） technology in early liver cirrhosis. Methods Sixty healthy volunteers（ control group） and forty patients with histologically proved early liver cirrhosis （ early liver cirrhosis group） were examined by ASQ. The original ultrasonic echo signal of the liver parenchyma was analyzed. The chi-square histogram and relevant parameters （ Red Mode,Red Ave,Red SD, Blue Mode,Blue Ave,Blue SD and FD ratio） were recorded and comparatively analyzed. Receiver operating char-acteristic （ ROC） curves were drawn for each parameter, and the critical values were obtained by ROC curves. Re-sults Statistically significant differences in Red Mode,Red Ave,Red SD,Blue Mode,Blue Ave,Blue SD and FD ratio were found between control group and early liver cirrhosis group （ P〈0. 01 ） . ROC showed that the curves of the seven parameters were in the upper left corner. The areas under the ROC curves（AUC） were greater than 0. 7, compared with AUC equals 0. 5 , statistically significant differences were found between them （ P〈0. 01 ） . Among these parameters, the AUC of FD ratio was greater than 0. 9, the critical value of which was 0. 10, with high sensi-tivity （76%） and specificity （98. 2%） . Conclusion ASQ is a new technology for the detection of early cirrhosis, which parameters,especially the FD ratio, has certain application value in the quantitative assessment of early liver cirrhosis.