埃博拉病毒和埃博拉病毒病研究文献计量学分析

Bibliometric analysis on research of Ebola virus and Ebola virus disease

目的 了解国际上埃博拉病毒和埃博拉病毒病研究领域现状.方法 以PubMed数据库为数据源,跨度为PubMed数据库所涉及的全部时间范围,利用书目共现分析系统和SPSS 19.0软件建立高频主题词词篇矩阵和共现矩阵,并进行聚类分析,使用Ucinet 6.0软件绘制可视化社会网络.结果 共检出埃博拉病毒和埃博拉病毒病研究文献1 384篇,文献始于1979年,发文量随着年代和疫情暴发情况呈增长趋势.欧美国家发文量1 213篇（87.6％）.27个核心主题词聚类分析显示,自1979年至2014年埃博拉病毒和埃博拉病毒病研究重点集中在3个领域：埃博拉病毒基因组结构和病毒蛋白研究,尤其是包膜蛋白;埃博拉病毒免疫学研究及动物模型的建立;埃博拉病毒病的流行病学及诊断治疗.社会网络显示,埃博拉病毒病的防控、埃博拉病毒基因学和免疫学处于核心地位.结论 埃博拉病毒和埃博拉病毒病文献发表已有35年,美国和英国是此领域研究大国.目前的研究为研制有效疫苗及诊断试剂奠定了重要基础.

Objective To get a knowledge of the current status of international research on Ebola virus and Ebola virus disease （EVD）.Methods All the articles about EVD from PubMed database were retrieved and analyzed.After core subject headings had been identified by BICOMB,the co-occurrence matrix was established.Cluster analysis about co-occurrence matrix was performed by SPSS 19.0.The visualized network image was drawn by Ucinet 6.0.Results A total of 1 384 literatures were involved in the analysis,with the earliest one published in 1979.The number of literatures was increasing along with time and disease outbreaks.Totally 1 213 （87.6％） literatures were published by Europe and U.S.There were 27 core subjects and they were clustered into 3 research areas from 1979 to 2014,including Ebola virus genome structure and viral proteins,especially the envelope protein; immunology of Ebola virus and animal models; epidemiology,diagnosis and treatment of Ebola hemorrhagic fever.The visualized social network reflected that the prevention of EVD,the genome and immunology of Ebola were the major concerns.Conclusion It has been 35 years since the literatures on Ebola virus and EVD emerged.The United States and the United Kingdom are the top two countries in this field.The present studies have laid a crucial foundations for developing effective vaccines and diagnostic reagents.