变应性鼻炎特异性免疫治疗的疗效

Efficacy of specific immunotherapy in treating allergic rhinitis

目的评价变应原特异性免疫治疗(SIT)对螨虫引起的常年变应性鼻炎的疗效。方法90例以尘螨为主要变应原的中-重度常年性变应性鼻炎患者分为两组:A组60例,采用SIT治疗及必要时药物对症治疗;B组30例,仅采用药物治疗。比较两组治疗前、治疗6个月和12个月症状的VAS评分和用药评分变化。结果治疗6个月和12个月后,两组VAS评分均较治疗前下降(P<0.05);A组低于B组(P<0.05)。治疗后A组用药评分下降,B组无明显变化。治疗12个月后,A组有效率93.33%,高于B组的76.67%(P<0.05)。结论 SIT对于尘螨引起的常年性变应性鼻炎有较好的疗效。

Objective To evaluate the efficacy of specific immunotherapy （SIT）for allergic rhinitis. Methods A total of 90 patients with perennial allergic rhinitis induced by mite was randomized into two groups of A（treated by SIT＋conventional medicine, 60 cases） and B（treated by conventional medicine alone, 30 cases）. The VAS symptom scores and medication scores were recorded in the 6th month and 12th month of treatment. Results The VAS scores of two groups after treatment were reduced significantly compared to those before（P〈0. 05）, which were lower in group A than those in group B（P〈0. 05）. The medication scores after treatment were reduced only in group A. The effectiveness rate was higher in group A than that in group B（93. 33% vs. 76.67%） （P〈0. 05）. Conclusion The efficacy of SIT is better than drug treatment alone in the patients with perennial allergic rhinitis induced by mite.