艾滋病合并肺孢子菌肺炎6例临床分析

An analysis of six AIDS cases with pneumocystis pneumonia

目的探讨艾滋病合并肺孢子菌肺炎(PCP)的临床特征。方法回顾性分析6例艾滋病合并PCP的临床资料。结果艾滋病合并PCP常见的临床表现为发热、进行性呼吸困难、咳嗽,较常见的伴随症状为体重下降及水样便。外周血CD4+T淋巴细胞比率下降(2.68±2.69)%,乳酸脱氢酶(LDH)升高(492.50±170.84)U/L,1-3-β-D葡聚糖水平升高(490.53±205.03)pg/ml。高分辨率CT(HRCT)显示非特异性多形性改变。结论艾滋病合并PCP的临床表现具有一定的特征,结合影像学及实验室检查有助于提高该病的早期诊断水平。

Objective To explore the clinical characteristics of pneumocystis pneumonia（PCP） in the patients with acquired immune deficiency syndrome（AIDS）. Methods Clinical data of six AIDS patients with PCP were retrospectively analyzed. Results In AIDS patients with PCP, the common presentations were fever,progressive dyspnea and cough, and the common associated symptoms were weight loss and watery stools. The CD4＋ T-lymphocyte ratio in peripheral blood was lowered[（2.68±2.69） %], serum levels of lactate dehydrogenase （LDH） and （ 1-3 ）-beta-d-glucan were increased [（492. 50±170. 84） U/L and （490. 53±205.03） pg/ml]. High resolution CT（HRCT） showed a wide variety patterns and nonspecific changes. Conclusion The clinical manifestations of AIDS patients with PCP have certain characteristics. Combined analysis of HRCT appearances and laboratory examinations is helpful in improving early diagnosis of PCP in the patients with AIDS.