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造血干细胞移植后急性移植物抗宿主病的预测及诊断标志物研究进展 被引量：2

Advances in prediction and diagnostic biomarkers on acute graft-versus-host disease after allogeneic stem cell transplantation
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摘要 急性移植物抗宿主病（aGVHD）是异基因造血干细胞移植（allo-HSCT）后的主要并发症之一,通常发生于移植后100天内,其发生率为35％～ 64％,影响患者的生活质量和长期生存,也是非复发死亡（NRM）的主要原因.因此早期诊断并给予及时正确的治疗具有十分重要的意义.但到目前为止,aGVHD的诊断仍是以患者的临床症状结合实验室检查结果及有创性组织活检作为最终确诊的手段.其发病机制包括3个连续的阶段：①预处理阶段由于药物或全身照射引起宿主组织细胞损伤,释放大量细胞因子如IL-2、TNF-α等,并激活宿主的抗原提呈细胞（APC）;②活化的宿主APC与大量细胞因子共同作用激活供者T淋巴细胞,使其活化、增殖、分化;③活化的供者T细胞和细胞因子共同作用于靶器官,导致组织器官损伤,出现aGVHD的临床症状.
作者 王紫薇 王健民
机构地区 第二军医大学附属长海医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2015年第2期172-176,共5页 Chinese Journal of Hematology
基金 国家自然科学基金（81090413、81270638）
关键词 急性移植物抗宿主病 异基因造血干细胞移植 诊断标志物 移植后 实验室检查结果 AGVHD 预测 组织细胞损伤
分类号 R457.7 [医药卫生—治疗学]
  • 相关文献

参考文献36

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二级参考文献7

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共引文献5

同被引文献20

  • 1GoyalRK, GoyalM, SankaranarayanK. Grading acute graft-versus-host disease: time to reconsider [J]. Pediatr Transplant, 2015, 19(3):252–254. doi: 10.1111/petr.12433.
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引证文献2

二级引证文献4

中华血液学杂志
2015年 第2期

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