药疹患者中人类疱疹病毒6型感染及TGF-β1的检测

Human Herpesvirus-6 Infection and The Test of Transforming Growth Factor-β1 in Drug Eruption Patients

目的探讨人类疱疹病毒6型感染及TGF-β1在药疹发病中的作用。方法收集62例药疹患者和64名正常对照者,采用ELISA法检测实验组和对照组血清中HHV-6 Ig G,HHV-6 Ig M和TGF-β1水平。结果实验组和对照组HHV-6 Ig G阳性率为85.48%和70.31%,差异有统计学意义(P<0.05)但其HHV-6 Ig M阳性率差异无统计学意义(P>0.05),其TGF-β1分别为22.23±4.73ng/m L和11.57±3.01 ng/m L,有或无HHV-6活动性感染组TGF-β1值分别为30.51±3.66 ng/m L和17.33±3.3ng/m L,差异均有统计学意义(P均<0.01)。结论药疹患者HHV-6潜伏感染率较健康者高,且有HHV-6活动性感染的药疹患者临床表现严重。TGF-β1的升高与药疹患者HHV-6活动性感染有关。HHV-6感染率和TGF-β1均在药疹中发挥一定作用。

Objective To investigate the role of human herpesvirus 6 （HHV-6） infection and transforming growth factor- β1 （ TGF-β1 ） in drug eruptions. Methods Sixty-two drug eruption patients and 64 healthy controls were in- volved. ELISA method was used to detect the HHV-6 lgG,HHV-6IgM,TGF-β1. Results The positive rate of HHV-6 IgG in the experimental group and control group were 85.48% and 70.31%. The difference was statis- tically significant （ P 〈 0. 05 ）. But the difference of positive rate of HHV-6 IgM between the experimental group and control group showed no significance. The TGF-β1 in experimental group and control group were 22. 23 ± 4.73ng/mL and 11.57 ± 3.01 ng/mL. The TGF-β1 in drug eruption patients with or without HHV-6 in- fection groups were 30.51 ± 3.66ng/mL and 17.33 ± 3.3 ng/mL. Both difference had statistical significance （ P 〈 0.01 ）. Conclusion The HHV-6 latent infection rate in patients with drug eruption is higher than that in healthy controls. The clinical manifestations are severe in drug eruption patients who have HHV-6 active infec- tion. The rise of TGF-β1 is related with HHV-6 active infection in patients with drug eruption. HHV-6 infection and TGF-β1 play a role in drug eruption.