银屑病与高血压病的相关性分析

The Correlation between Psoriasis and Hypertension

目的评价银屑病、银屑病性关节炎与高血压病的相关性。方法计算机检索多种数据库,评价纳入文献的质量及提取资料后,运用Rev Man 5.0软件对符合标准的银屑病及银屑病性关节炎与高血压病相关性的研究进行Meta分析。结果纳入关于银屑病与高血压病的文献共29篇,结果显示银屑病与高血压病具有相关性[OR=1.68,95%CI(1.50,1.87)]。轻度及重度银屑病与高血压病具有相关性[OR=1.27,95%CI(1.24,1.30)];[OR=1.48,95%CI(1.35,1.62)]。纳入关于银屑病性关节炎与高血压病的文献共7篇。银屑病性关节炎与高血压病具有显著相关性[OR=2.33,95%CI(1.44,3.76)]。结论在目前的数据支持下,无论银屑病严重程度,银屑病与高血压病均有相关性,银屑病性关节炎与高血压病有显著相关性。提示银屑病和银屑病性关节炎可能增加高血压病的患病风险。

Objective To assess the correlation between psoriasis （PsO）/psoriatic athritis （PsA） and hypertension （HPN） ,and the correlation between PsO and HPN basing on different severity and regions. Methods We searched database to collect studies of the association between PsO, PsA and HPN according to the criteria. E- valuate the quality of included studies, extracted data and performed meta-analyses by using the RevMan 5.0 software. Results A total of 29 studies on PsO and HPN were included in. The pooled analysis showed the PsO group associated with HPN [ OR = 1.68,95% CI（1.50,1.87） ]. The mild or severe PsO group associated with HPN [ OR = 1.27,95 % CI（1.24,1.30） ], [ OR = 1.48,95 % CI（ 1.35,1.62 ） ]. The PsA group associated with HPN significantly[ OR = 2.33,95% CI（1.44,3.76） ]. Conclusion Based on the research data, regard- less of PsO severity, PsO and HPN are correlated. The correlation also exists between PsA and HPN, suggesting that PsO or PsA may increase the risk of HPN.