皮肤镜动态监测白癜风63例治疗后色素恢复情况

Function for Monitoring Skin Pigment Recovery of 63 Patients with Vitiligo by Dermoscopy

目的评价应用皮肤镜动态观测白癜风患者治疗后皮损区色素恢复情况的作用。方法收集63例白癜风患者,在初次就诊时、治疗后4周、8周、12周时分别进行皮肤镜监测和对比。结果肉眼观察皮损区域出现复色的患者中,皮肤镜下都可见明显色素岛形成;肉眼观察皮损区域无明显复色的患者中,在皮肤镜下,部分患者未见明显色素岛形成,部分患者可见少量色素岛形成。肉眼观察治疗后4周、8周、12周时的平均有效率分别为14.29%、28.57%、52.38%,皮肤镜观察治疗后4周、8周、12周的平均有效率分别为23.81%、41.27%、61.90%,差异均有统计学意义(P<0.05)。结论皮肤镜可以作为评估白癜风疗效的有效手段,其可在早期准确而科学的评价治疗效果,从而增加患者治疗信心,适合科学评价药物疗效。

Objective To evaluate the function of dermoscopy for monitoring dynamically the pigment recovery of the lesions of vitiligo patient. Methods Sixty-three patients with vitiligo monitored and contrasted respective- ly by dermoscopy at the initial visit,4 weeks, 8 weeks, 12 weeks after treatment. Results Patients with le- sions appear visually repigmented area, clearly visible reservoirs of pigmentation could be observed by der- moscopy ;in patients with no obvious repigmented area by naked eye, part of patients had no obvious reser- voirs of pigmentation could be observed by dermoscopy, part of the patients had a few visible reservoirs of pigmentation could be observed by dermoseopy. Naked eye observation after the treatment of 4 ,g, 12 week, average efficiency were 14.29% ,28.57% ,52.38%. Dermoscopy observation after the treatment of 4,8, 12 week, average efficiency were 23.81%, 41.27%, 61.90%, the difference was statistically significant （P 〈 0.05 ）. Conclusion Dennoscopy can be used as effective means of vitiligo therapy assessment, which could provide accurate and scientific evaluation of treatment effect in early period, increased the confidence of the patient, evaluated the drug efficacy scientifically.