白芍总苷胶囊联合依巴斯汀片治疗慢性湿疹42例临床观察

Clinical Investigation of Total Glucoside of Paeony Combine with Ebastine in the Treatment of Chronic Eczema

目的评价白芍总苷胶囊联合依巴斯汀片治疗慢性湿疹的临床疗效和安全性。方法 126例慢性湿疹患者随机分为3组,各42例。A组口服白芍总苷胶囊2粒,3次/d,依巴斯汀片10mg,1次/d;B组单纯口服依巴斯汀,C组单纯口服白芍总苷胶囊,用法均同治疗组。三组患者均外用曲安奈德乳膏,2次/d,连续治疗2周为一疗程。结果 A组有效率为88.10%,B组为64.29%,C组为57.14%。A组与B组和C组疗效差异均有统计学意义(P=0.01,0.002);B组与C组疗效差异无统计学意义(P=0.393)。三组患者均无明显不良反应。结论白芍总苷胶囊联合依巴斯汀片治疗慢性湿疹安全而有效。

Objective To investigate the clinical effect and safety of total glucosideof paeony combine with ebastine in the treatment of chronic eczema. Methods One hundred and twenty-six outpatients with chronic eczema were divided into group A, B and C randomly. Forty-two patients in group A took capsule of total glucoside of paeony two capsules, three times a day and ehastine tablet 10rag/day. Forty-two patients in group B took took ebastine tablet lOmg/day. Forty-two patients in group C took capsule of total glucoside of paeony two cap- sules, three times a day. Mometasone furoate cream was used externally 2 times/day in 3 groups for 2 weeks. Results The total effective rate in group A was significantly higher than that of group B and C （P = 0.01, 0. 002）. The total effective rate in group B was no statisticaly significant as compared to group C （ P = 0. 393）. Conclusion This investigation indicates that total glucosideof paeony combine with ebastine is an effective and safe therapy in the treatment of patient with chronic eczema.