microRNA调控肿瘤微环境的研究进展

Research Progress of microRNA in Regulating Tumor Microenvironment

目的总结micro RNA对肿瘤微环境的调控机制。方法通过检索Pub Med获取近年来关于micro RNA对肿瘤细胞微环境调控机制的相关文献资料并进行综述。结果 micro RNA可以参与低氧诱导因子、肿瘤相关成纤维细胞、细胞外基质等肿瘤微环境因素在转录后水平表达的调控,微环境的变化会导致肿瘤细胞生物学行为的改变。结论 micro RNA参与调节肿瘤微环境的诸多因素,而微环境的改变对于肿瘤的发生、发展有着至关重要的作用,明确micro RNA对微环境调控的机制不仅有助于探索肿瘤细胞生物学行为,同样为肿瘤疾病的诊断和预后提供新的思路。

Objective To summarize the regulating mechanism of micro RNA in tumor microenvironment. Method The literatures about the studies on the mechanism regulated by micro RNA for tumor microenvironment were reviewed according to the results searched from Pub Med in recent years. Results micro RNA might be participated in regulation of tumor microenvironment factors such as hypoxia-inducible factor, tumor associated fibroblasts, extracellular matrix, which leaded to a change in biological behavior of tumor cells by reforming the microenviroment. Conclusions micro RNA has been participated in regulating many factors of tumor microenvironment. The change of neoplastic microenvironment has been recognized to play a critical role in the development of cancer. Therefore revealing micro RNA mechanism for tumor microenvironment could not only help exploring the biological behavior of tumor cells, but also come an important insight for new means of diagnosis and treatment of cancer.