FibroTouch与FibroScan在慢性乙型肝炎患者肝纤维化评估中的比较

Comparison of FibroTouch and FibroScan for the assessment of fibrosis in chronic hepatitis B patients

目的 评估FibroTouch与FibroScan两种瞬时弹性测定仪检测慢性乙型肝炎患者肝脏硬度值的相关性,比较两种仪器检测的成功率.方法 收集2013年6月至11月就诊的慢性乙型肝炎、肝硬化代偿期患者资料,分别用FibroScan（A组）、FibroTouch超声定位点（B组）和FibroScan相同定位点（C组）两种仪器检测肝纤维化程度,比较两种仪器检测结果的一致性;并对慢性乙型肝炎、肝硬化代偿期两组患者的硬度值比较。结果 A组、B组、C组对211例患者肝纤维化程度检测值分别为5.30（4.30,8.65）和6.10 （4.70,8.90）、5.70 （4.50,8.00）,将结果进行配对t检验,差异无统计学意义（P＜0.05）;采用Person相关分析,相关系数均为＞0.8（P＜0.05）,两种仪器检测结果相关性良好.慢性乙型肝炎、肝硬化代偿期两组硬度值的差异有统计学意义（P＜ 0.05）。FibroTouch与FibroScan两种瞬时弹性测定仪成功率为100％和97％。结论 FibroTouch与FibroScan两种瞬时弹性测定仪检测肝脏纤维化程度一致性较好。FibroTouch仪器检测成功率高于FibroScan。

Objective To perform a comparative assessment of the performance of FibroTouch and FibroScan in patients with hepatitis B.Methods A total of 211 patients with hepatitis B,including cases of chronic hepatitis B （CHB） and of cornpensated cirrhosis,were enrolled for study between June and November of 2013.The patients underwent FibroScan testing （group 1） and FibroTouch testing （group 3）,after which the operator examined a timemotion ultrasound image from the FibroScan test and located a specific liver portion for focused FibroTouch testing （group 2）.The consistency between the two tests＇ results was investigated by Pearson＇s correlation analysis,and the difference of liver stiffness between CHB patients and compensated cirrhosis patients was investigated by the two independent samples t-test or Mann-Whitney U test.Results The values of liver stiffness were 5.30 （4.30,8.65） in group 1,6.10 （4.70,8.90） in group 2,and 5.70 （4.50,8.00） in group 3 （allP 〈 0.05）; the Pearson correlation coefficients were all 〉 0.8 （P 〈 0.05） and there was no statistically significant difference found between the results from FibroScan and FibroTouch.The values of liver stiffness were significantly different between the CHB patients and the compensated cirrhosis patients （P 〈 0.05）.The rates of successful detection were 100% for FibroTouch and 97% for FibroScan.Conclusions FibroTouch and FibroScan have good consistency in the evaluation of the degree of liver fibrosis.FibroTouch has a higher rate of successful detection than FibroScan.