自然杀伤细胞在血液肿瘤免疫治疗中的应用及研究进展

Application and advances of natural killer cells in blood cancer immunotherapy

自然杀伤（NK）细胞为机体固有免疫系统效应细胞,无需抗原预先致敏即可识别并杀伤肿瘤等异常细胞,参与免疫监视功能,移植物排斥反应与自身免疫疾病的发生.NK细胞对血液肿瘤细胞的杀伤活性主要取决于其细胞表面活化性受体与抑制性受体分别识别血液肿瘤细胞相应配体后产生的信号强度的综合.随着对NK细胞对肿瘤细胞杀伤作用机制的深入研究,以NK细胞为基础的血液肿瘤过继免疫治疗备受关注.

Natural killer （NK） cells important effector cell of innate immune system,it could recognize and kill cancer or other abnormal cells in the absence of antigen sensitization.It＇s involved in immune surveillance,graft rejection and autoimmune diseases.The cytotoxicity of NK cell against blood cancer cells depends on the signal strength of activity receptors and inhibitory receptors expressed on NK cell combined to their ligands expressed on blood cancer cells respectively.With the in-depth study on the mechanisms of NK cells cytotoxicity against cancer cells,NK cell-based adoptive immunotherapy against blood cancer receives much more concern.