联合检测CRP、BNP和cTnI在急性心肌梗死患者中的临床意义

Clinical significance of combined detection of CRP, BNP and cTnI in patients with acute myocardial infarction

目的探讨高敏C反应蛋白(hs-CRP)、B型钠尿肽(BNP)、心肌肌钙蛋白I(c Tn I)联合检测在急性心肌梗死(AMI)患者中的临床意义。方法收集南昌大学第二附属医院收治193例首发AMI患者,分别测定静脉血hs-CRP、BNP及c Tn I水平,并分析三项指标的水平变化与住院和随访期发生主要心血管事件(MACE)的关系。结果 AMI患者CRP的中位数为8.35 mg/L,BNP的中位数为267.67 pg/ml,c Tn I的中位数为13.74 ng/ml,随各单项值升高,MACE的发生率均明显升高(P<0.01),病程短者MACE的发生率较病程长者明显增多(P<0.05)。结论 CRP、BNP及c Tn I水平与AMI患者病情和预后密切相关,联合检测可提高确诊率。

Objective To study the clinical significance of combined detection of high sensitive C reactive protein（hs-CRP）,B type natriuretic peptide（BNP） and cardiac troponin I（c Tn I） for the diagnosis of acute myocardial infarction. Methods 193 cases of AMI patients in our hospital were selected for the study and their serum levels of hs-CRP, BNP and c Tn I were determined. Major adverse cardiovascular events and levels of three indices of hospitalization and follow-up analysis（MACE）relationship were analyzed. Results The average serum levels of CRP, BNP and CTn I were 8.35 mg / L, 267.67 pg / ml, and13.74 ng / ml, respectively. With the increase in the levels, the incidence of MACE was significantly increased（P〈0.01）; the incidence of MACE of the patients with short duration of the disease was significantly more than patients with long duration of the disease（P〈0.05）. Conclusion The levels of CRP, BNP and c Tn I and state of illness and prognosis are closely related.Detection of these levels can improve the diagnosis rate.