肠道微生态失衡与非酒精性脂肪性肝病的关系

Relationship between intestinal microflora imbalance and nonalcoholic fatty liver disease

肠道微生态系统由定植于肠道的固有菌群、肠上皮细胞、肠黏膜免疫系统组成。非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感性相关的代谢应激性肝损伤。近年来关于肠道微生态与NAFLD发病机制关系的研究越来越多。肠道微生态失衡导致的肠道菌群过度生长、肠黏膜通透性增加、肠源性内毒素血症、炎症因子产生等在NAFLD的发生发展过程中扮演着重要的角色。深入研究肠道微生态失衡与NAFLD的关系将有助于为NAFLD的治疗及预防提供新方向。

The intestinal microecosystem is composed of natural microflora,intestinal epithelial cells,and intestinal mucosal immune sys-tem.Nonalcoholic fatty liver disease （NAFLD）is a metabolic stress-induced liver injury associated with insulin resistance and genetic sus-ceptibility.In recent years,there has been increasing evidence showing the involvement of imbalanced intestinal microflora in the pathogene-sis of NAFLD.Overgrowth of intestinal microflora,increased permeability of intestinal mucosa,intestinal endotoxemia,and production of in-flammatory cytokines play important roles in the development of NAFLD.Further studies on the relationship between intestinal microflora im-balance and the pathogenesis of NAFLD may shed light on the treatment and prevention of NAFLD.