复方玄驹胶囊配合西药治疗多囊卵巢综合征临床观察

Clinical observation of administration of Xuanju capsule combined with Diane-35 and letrozol on polycystic ovarian syndrome

目的探讨复方玄驹胶囊联合达英-35、来曲唑等治疗多囊卵巢综合征的临床效果。方法采用随机化分组,将60例多囊卵巢综合征患者分为对照组和观察组。对照组(n=30)用达英-35和来曲唑治疗;观察组(n=30)用达英-35和来曲唑并加用复方玄驹胶囊。比较两组各激素水平、优势卵泡个数及排卵个数。结果对照组LH、FSH/LH比值在调整治疗前后差异有统计学意义(P<0.05);观察组血清睾酮(T)、LH、FSH/LH在调整治疗前后差异有统计学意义(P<0.05)。对照组治疗后孕酮(P)[(0.42±0.07)vs.(0.85±0.27)]和FSH/LH[(1.04±0.23)vs.(1.21±0.21)]较观察组有显著性差异,LH水平[(6.34±1.68)vs.(5.38±1.43)]显著高(P<0.05)。对照组治疗后排卵个数[(0.67±0.71)vs.(1.13±0.68)]显著少于观察组(P<0.05)。结论复方玄驹胶囊配合西药治疗多囊卵巢综合征不孕效果优于单用西药治疗。

Objective： To study the clinical effect of Xuanju capsule combined with Diane-35 and [etrozol in treatment of polycystic ovarian syndrome（PCOS）. Methods： Sixth patients with PCOS were randomly allocated into observation group and control croup. The patients in control group were treated with Diane-35 and letrozole. The patients in observation group were treated with Xuanju capsules combined with Diane-35 and letrozole. The LH levels,the ratio of FSH/LH, the number of dominant follicles and oocytes ovulated were compared before and after treatment between the two groups. Results： The levels of LH,FSH/LH were significantly different before and after treatment in control group（P（0.05） ,and the levels of testosterone and LH, FSH/LH were significantly different before and after treatment in observation group（P〈0.05）. The progesterone levels（0.42±0.07 vs. 0. 85±0. 27）and FSH/LH（1. 04± 0. 23 vs. 1.21± 0.21）were significantly lower and LH levels（6.34 ± 1.68 vs. 5.38 ± 1.43）were significantly higher after treatment in the control group than those in observation group（P〈 0.05）. The number of oocytes ovulated after treatment in the control group（0.67±0.71 vs. 1.13±50.68） were significantly less than that in observation group（P〈0.05）. Conclusions： The effect of Xuanju capsule combined with Diane-35 and letrozole in treatment of polycystie ovarian syndrome is better than Diane-35 and letrozole therapy alone.