吉林农村居民饮酒与血脂异常的关系研究

Rlationship between Alcohol Consumption and Dyslipidemia among Rural Residents in Jilin Province

目的 探讨吉林农村居民饮酒与血脂异常的关系.方法 为横断面调查,采取分层整群随机抽样方法,对吉林省东丰县、靖宇县农村居民进行流行病学问卷调查表与体格、血液检查相结合的方式进行调查,血脂异常定义为：符合①总胆固醇（total cholesterol,TC）≥6.22mmol/L;②甘油三酯（triglyceride,TG）≥2.26mmol/L;③低密度脂蛋白胆固醇（low-density lipopro-tein cholesterol,LDLC） ≥4.14mmol/L;④高密度脂蛋白胆固醇（high-density lipoprotein cholesterol,HDLC）＜1.04mmol/L或HDLC≥1.55mmol/L其中至少1项的,规定为血脂异常.运用x2检验及多因素Logistic回归进行统计学分析.结果 本次调查所得有效样本2601例（男性1179例,女性1422例）,饮酒率为21％（男性44.3％,女性1.7％）,男女性血脂异常患病率分别为63.5％和64.4％.随每日饮酒量的增加,男性血脂异常率、HDLC和TG血清浓度也在增加（P=0.000）.中量饮酒和大量饮酒者中,TC浓度高于其他组（P=0.000）.调整所有混杂因素后的多因素Logistic回归显示,中量饮酒组TG异常与不饮酒组相比,OR =2.22,95％ CI：1.50～3.29,HDLC异常的OR=1.58,95％ CI：1.17～2.13;大量饮酒组,HDLC异常的OR=1.78,95％ CI：1.25 ～ 2.55,TC异常的OR=2.36,95％ CI：1.31～4.22,TG异常的OR=2.87,95％ CI：1.86～4.45.结论 饮酒是男性高密度脂蛋白胆固醇异常、总胆固醇异常和甘油三酯异常危险因素,其中TC总胆固醇异常与大量饮酒（＞80g/d）有关,甘油三酯异常对男性饮酒量变化更敏感.

Objective To explore the relationship between alcohol intake and the prevalence of dyslipidemia. Methods We con- ducted a cross - sectional epidemiologieal study using stratified cluster random sampling in 2013 within Dongfeng county and Jingyu coun- ty, Jilin province, including all residents aged over 35 in the 4 villages random selected within each county. The risk factors were collect- ed by using a epidemiological questionaires, physical measurements and blood tests. The diagnosis of dyslipidemia were anyone with TC ≥ 6.22mmol/L, TG ≥ 2.26mmol/L, HDLC 〈 1.04mmol/L or HDLC ≥ 1.55mmol/L. Statistical methods such as chi - square test and logis- tic regression were used. Results We got 2601 valid samples, including 1179 males and 1422 females. A greater proportion （44.3%） of males reported consuming alcohol compared to females （ 1.7% ）. As the increase of alcohol - consuming, the rate of dyslipidemia in males, and the serum concentration of HDLC and TG increased （P = 0. 000）. The serum concentration of TC was higher than the others in male alcohol drinkers who consumed 20 - 80g alcohol/d and 〉 80g alcohol/d. After all confounders adjusted, the odds ratios of TG and HDLC disorders were 2.22 （95 % CI ： 1.50 - 3.29 ） and 1.58 （ 95 % CI ： 1.17 - 2.13 ） respectively in male alcohol drinkers who consumed 20 -80g alcohol/d compared with abstainers and the odds ratios of TC, HDLC and TG were 1.78 （95% CI： 1.25 -2.55 ） , 2.36 （95% CI： 1.31 - 4.22 ） and 2.87 （95% CI ： 1.86 - 4.45） respectively in male alcohol drinkers who consumed 〉 80 g alcohol/d. Conclusion Alcohol consumption increased the risk of disorders of HDLC, TC and TG, and hypercholesterolemia was related with heavy alcohol consumption. The hypertriglyceridemia was the easiest to be influenced by the increase of alcohol intake in males.