地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹的临床观察

Clinical Effect of Desloratadine and Compound Glycyrrhizin Tablets in Patients with Chronic Urticaria

目的 观察地氯雷他定联合复方甘草酸苷对慢性荨麻疹患者的临床疗效.方法 将笔者医院从2013年1～6月收治的140例慢性荨麻疹患者按随机数表法均分为实验组70例和对照组70例,实验组采用地氯雷他定联合复方甘草酸苷治疗,对照组单用地氯雷他定治疗.比较两组CD4^＋和CD8^＋淋巴细胞比例的变化、临床疗效、治疗后复发率以及药物不良反应的发生率.结果 治疗前两组CD4^＋和CD8^＋淋巴细胞亚群比例差异无统计学意义（P＞0.05）;治疗后,CD8^＋淋巴细胞两组均出现显著减低（P＜0.05）,CD4^＋淋巴细胞和CD4^＋/CD8^＋比值两组均出现显著升高（P＜0.05）,但治疗后实验组CD4^＋淋巴细胞和CD4^＋/CD8^＋比值均显著高于对照组（P＜0.05）,而CD8^＋淋巴细胞实验组又显著低于对照组（P＜0.05）.实验组临床治疗有效率为87.1％显著高于对照组的75.8％（P＜0.05）.随访6个月后实验组和对照组复发率分别为55.7％和72.9％,两组之间差异具有统计学意义（P＜0.05）.实验组不良反应发生率为8.6％,对照组不良反应发生率为7.1％,两组之间差异无统计学意义（P＞0.05）.结论 地氯雷他定联合复方甘草酸苷能有效治疗慢性荨麻疹,安全有效,且能减少复发.

Objective To study the clinical effect of desloratadine and compound glycyrrhizin tablets in patients with chronic urticar- ia. Methods Totally 140 patients with chronic urticaria in our hospital from January 2013 to June 2013 were divided into 2 groups： ex- perimental group（n =70） and control group（n = 70）. The experimental group was treated with desloratadine and compound glyeyrrhizin tablets, and the control group was treated with desloratadine. The change of lymphocyte subtype, clinic effects, recurrence rate and side effects were compared between the two groups. Results There was no statistically significant differences of lymphocyte subtype between experimental and control group at pretreatment （ P 〉 0.05 ）. After treatment, the CD8^＋ lymphocytes were decreased （ P 〈 0.05 ） , and CD4^＋ lymphoeytes and CD4^＋/CD8^＋ values were increased subtype in the two groups（ P 〈 0.05 ）. However, at posttreatment, CD8^＋ lym- phocytes were lower in experimental group than those in control group（P 〈 0.05） , and CD4^＋ lymphocytes and CD4^＋/CD8^＋ values were higher in experimental group than that in control group （P 〈 0.05）. The clinic effective rate in experimental group was 87. 1% , which was higher than that of 75.8% in control group （ P 〈 0.05 ）. The recurrence rate was 55.7% and 72.9% in experimental and control group. There was significant difference between the two groups（P 〈 0.05 ）. The rate of side effects in experimental group was 8.6% , and in control group was 7.1%. There was no significant difference of side effects between the two group（ P 〉 0.05 ）. Conclusion Deslorata- dine and compound glycyrrhizin tablets showed effectively clinical efficacy and safty to chronic urticaria patients, and decreased the rate of recurrence. The regulation of immune function maybe contribute its action mechanisms.