强直性脊柱炎患者脊柱骨赘的分布及其与病程的关系

Distribution of Spinal Syndesmophytes and the Relationship between Syndesmophytes and Disease Duration of Ankylosing Spondylitis

【目的】探讨强直性脊柱炎患者脊柱韧带骨赘的分布及其与病程的关系。【方法】于2013-2014年符合1984年纽约标准的强直性脊柱炎患者纳入本研究。所有患者均进行了骶髂关节、颈胸腰椎正侧位X线片等相关检查。我们分析了相应的临床资料、实验室检查结果和影像学资料。【结果】82名强直性脊柱炎患者的平均年龄为(27.4±7.7)岁,平均病程为(6.1±6.1)年,65.85%的患者有超过一个的韧带骨赘。腰椎、胸椎和颈椎受累比例分别为51.22%、0.08%和29.26%。腰椎骨赘比颈椎、胸椎骨赘更为多见。有骨赘组的平均病程明显长于无骨赘组(P=0.001)。随着病程增加,全脊柱平均韧带骨赘数随之增多。【结论】强直性脊柱炎患者脊柱韧带骨赘的分布以腰椎多见,疾病病程的长短与脊柱骨赘数正相关,与疾病炎症指标无关。

【Objective】 To evaluate the distribution of spinal syndesmophytes and to explore the relationship between spinal syndesmophytes and disease duration of ankylosing spondylitis.【Methods】 Patients who were diagnosed with ankylosing spondylitis between 2013 and 2014 according to the 1984 revised New York criteria were included into our study.All patients had received X-ray of sa＇croiliac joint,cervical,thoracic and lumber vertebra.We analyzed their clinical data,laboratory examination and radiography results.【Results】 A total of 82 ankylosing spondylitis patients were included with a mean age of 27.4 ± 7.7 years old and a average disease duration of 6.1±6.1 years.65.85% of total patients had syndesmophytes.The proportion of lumber,thoracic and cervical vertebra involvement were 51.22%,0.08%,and 29.26%,respectively.Syndesmophytes of lumber vertebra were more common than thoracic and cervical vertebra.The disease duration of syndesmophytes group was longer than group without syndesmophytes（P =0.001）.The average number of syndesmophytes rises with the increase of disease duration.【Conclusion】 The distribution of spinal syndesmophytes of ankylosing spondylitis was commonly seen in lumber vertebra.The length of disease duration was associated with the number of spinal syndesmophytes.Otherwise,there was no relationship between the number of spinal syndesmophytes and inflammation index of disease found in this study.