非急性期肺血栓栓塞患者血浆ADAMTS-13及炎症因子变化

Variation in ADAMTS-13 and Inflammatory Factor in Non-acute Pulmonary Thromboembolism Patients

【目的】探讨肺动脉血栓栓塞症(PTE)患者血管性血友病因子裂解酶(ADAMTS-13)水平及其与炎症反应的关系。【方法】采用酶联免疫吸附的方法 (ELISA)测定25例我院呼吸科门诊随访病程超过3个月的PTE患者、15例健康对照者的外周血血管性血友病因子(v WF)、ADAMTS-13、C反应蛋白(CRP)、白介素6(IL-6)。【结果】PTE组及健康组血浆v WF水平分别为136.89(78.90)ng/m L、57.12(25.23)ng/m L,PTE组v WF水平高于健康组(P<0.001)。PTE组及健康组血浆ADAMTS-13水平分别为213.34±52.39 ng/m L、354.71±79.02 ng/m L,PTE组ADAMTS-13水平显著低于健康对照组(P<0.001)。多重线性回归分析显示血浆ADAMTS-13水平与血浆v WF水平呈负相关(r=-0.490,P=0.013)PTE组及健康组血浆IL-6水平分别为2.59(2.34)pg/m L、1.70(0.71)pg/m L,PTE组IL-6水平高于健康组(P<0.05)。【结论】PTE患者在急性发作后相当长的一段时间内仍存在血浆ADAMTS-13水平的下降及非特异性的炎症反应。

【Objective】 To explore the variation of ADAMTS-13 level and its relationship with inflammation in patients with pulmonary thromboembolism（PTE）.【Methods】 ELISA was performed to detect plasma v WF,ADAMTS-13,CRP,IL-6 in 25 patients with PTE,who were diagnosed over 3 months,from respiratory outpatient department of our hospital.Negative control group was established by 15 healthy blood donors.【Results】 The levels of v WF in PTE group and healthy group were 136.89（78.90）ng/m L and 57.12（25.23）ng/m L,respectively.VWF levels were higher in PTE group than in healthy group（P0.001）.The plasma level of ADAMTS-13 in PTE group was 213.34±52.39 ng/m L,lower than that in healthy group（354.71±79.02 ng/m L,P0.001）.Multiple linear regression analysis showed that there was significantly negative correlation between plasma ADAMTS-13 with v WF（r =-0.490,P= 0.013）.The plasma levels of interleukin（IL）-6 in PTE group and healthy group were 2.59（2.34） pg/m L,and 1.70（0.71） pg/m L,respectively.IL-6 levels were higher in PTE group than in healthy group（P 0.05）.【Conclusions】 It would be a considerable long time that a decline in plasma ADAMTS-13 levels and non-specific inflammatory reaction existed in patients with PTE after the acute episode.