抗结核药所致肝损害与药物代谢酶等基因多态性的关联性研究

Study progress on anti-tuberculosis drug-induced liver damage associated with drug-metabolizing enzyme gene polymorphism

肺结核是由结核分枝杆菌(MTB)感染引起的慢性传染病,是严重危害人类健康的传染病之一。抗结核药物所致肝损害(anti-tuberculosis drug-induced hepatotoxicity,ATDH)是结核病治疗过程中备受关注的问题。有关ATDH的致病机制尚不完全明确,深入探讨肝损害发生的机制显得尤为重要。抗结核药在体内经各种代谢酶及转运体作用形成毒性较低的产物,而这些酶的基因多态性很可能是影响ATDH的重要因素。本文就相关酶的基因多态性与ATDH致病原因作一概述。

Tuberculosis is a chronic infectious disease caused by mycobacterium and is one of the serious infectious diseases harmful to human health. Anti-tuberculosis drug-induced hepato- toxicity （ATDH） draws more attention in the treatment of tuberculosis recently. It is worthy of summarizing the detailed mechanism about ATDH which is still not clear today. It is known to us that anti-tuberculosis drugs are formed less toxic metabolite in vivo by various metabolic en-zymes and transporters, and the polymorphisms of transporters and enzymes are likely to be the important factors associated with ATDH. This paper provides an overview about the correlation between drug metabolic enzymes polymorphisms and ATDH.