摘要
目的探讨GHRP-6对心率昼夜节律的影响。方法给大鼠在体植入E-Mitter传感器,实时监测心率,观察GHRP-6对大鼠心率昼夜节律的影响。结果作为昼伏夜出动物,Wistar大鼠正常时夜间的心率较白天快。GHRP-6(100μg/kg)可使大鼠夜间心率显著减慢,而对白天的心率影响不大,导致心率的昼夜节律性降低。结论 GHRP-6使大鼠心率变化的日节律明显减弱,因此GHS-R信号通路可能对心脏活动日节律有调节作用。
Objective To investigate the effect of GHRP -6 on the circadian rhythm of heart rate. Methods E - Mitter, a heart rate （HR） sensor, was implanted subcutaneously by surgery in Wistar rats. Continuous real -time monitoring of HR was performed. Re- suits As nocturnal animals, rats showed faster HR at night than during the day. GHRP -6 （1001xg/kg） significantly decreased the HR at night, but did not significantly affect the HR in the day time. Therefore, GHRP - 6 decreased the circadian variation of HR in this spe- cies. Conclusion GHRP - 6 blunted the circadian oscillation of HR in Wistar rats, suggesting a role of GHSR in the regulation of cardi- ac activities.
出处
《医学研究杂志》
2015年第2期32-35,共4页
Journal of Medical Research
基金
国家自然科学基金资助项目(81071072)
