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免疫细胞的互噬作用在器官移植免疫耐受中的研究进展 被引量：4

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摘要 器官移植免疫耐受的诱导一直是移植免疫研究的热点。免疫细胞之间的相互作用，特别是调节性细胞对效应性细胞的调节和抑制，是诱导免疫耐受的关键。研究表明，抗原提呈细胞（APC）在和其他细胞接触时可以通过免疫突触进行细胞膜片段甚至细胞浆部分内容的交换，这个过程被称为免疫细胞的互噬作用（Trogocytosis）。
作者 赵国宪 贺强 韩东冬 李先亮
机构地区 首都医科大学附属北京朝阳医院肝胆胰脾外科
出处 《中华器官移植杂志》 CAS CSCD 2015年第1期55-58,共4页 Chinese Journal of Organ Transplantation
基金 国家自然基金面上项目（81273270、81471590） 国家自然科学基金委主任基金（81041110） 北京市自然基金面上项目（7122066、7122071）
关键词 移植免疫耐受 免疫细胞 器官 抗原提呈细胞 相互作用 免疫突触 细胞接触 调节性
分类号 R392 [医药卫生—免疫学]
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  • 3Zhang Q J, Li XL, Wang D, et al. Trogocytosis of MHC-Ⅰ/ peptide complexes derived from tumors and infected cells enhances dendritic cell cross-priming and promotes adaptive T cell responses. PLoS One 2008; 3:e3097.
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共引文献18

同被引文献31

  • 1赵峻,张莉蓉,乔海灵.免疫抑制剂硫唑嘌呤的药物不良反应[J].中国误诊学杂志,2006,6(5):839-841. 被引量：25
  • 2肖序仁,徐衍盛,敖建华.不同免疫抑制剂诱导外周血活化T淋巴细胞凋亡的研究[J].中华器官移植杂志,2006,27(11):644-647. 被引量：2
  • 3Jaime-P6rez JC, Colunga-Pedraza PR, G6mez-Ramirez CD, et al. Danazol as first-l'ine therapy for aplastic anemia. Ann Hematol, 2011, 90(5):523-527.
  • 4Pillai A,Hartford C,Wang C, et al. Favorable preliminary results using TLI/ATG-based immunomodulatory conditioning for matched unrdated donor allogeneie hematopoietic stem ceil transplantation in pediatric severe aplastic anemia[J]. Pediatr Transplant, 2011,15 (6) : 628-634.
  • 5Kanda Y, Oshima K, Kako S, et al. In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantatiom Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation. Am J Hematol, 2013, 88(4):294-300.
  • 6Hutspardol S, Sirachainan N, Anurathapan U, et al. Allogeneic hematopoietic stem cell transplantation for children with severe aplastic anemia. J Med Assoc Thai, 2013, 96 Suppl 1 :S18-24.
  • 7Aversa F, Terenzi A, Tabilio A, et al. Full haplotype- mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol, 2005, 23(15):3447-3454.
  • 8i Henslee-D, Godder K, Abhyankar S, et al. Sequential immuno- modulation to achieve engraftment and control graft-versus- host disease across mismatched MHC barriers. The AmericanSociety of Hematology Educational Program Book, 1999, 389- 394.
  • 9Mehta J, Singhal S, Gee AP, et al. Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia: single-center experience of 201 patients. Bone Marrow Transplant, 2004, 33 (4) : 389-396.
  • 10Luznik L, ODonnell PV, Symons HJ, et al. HLA- haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high- dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant, 2008, 14(6):641-650.

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中华器官移植杂志
2015年 第1期

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