CA125、HE4、AngⅡ联合检测在子宫内膜癌诊断中的应用价值

Study on the Application Value of Combined Detection of CA125,HE4,AngⅡ in the Diagnosis of Endometrial Carcinoma

子宫内膜癌(EC)的发生、发展是多因素造成的,故对其的检测研究也是多方面的。近年来,随着研究越来越系统,越来越多的肿瘤标志物被发现,每个肿瘤标志物均有其特异之处。如糖类抗原125对EC术后复发较敏感;人附睾分泌蛋白4的敏感性高,但高龄却是一大影响因素;而血管紧张素Ⅱ侧重于对EC的预后判定。该文就以上3种近年来研究较多的肿瘤标志物优劣势进行分析,对三者联合检测进行预测。

The occurrence and progression of endometrial cancer are caused by many factors,therefore,studies on the detection methods for the disease are various. In recent years,more and more tumor markers have been found as related research deepens,with specific advantages of their own.For example,carbohydrate antigen 125 is sensitive to the postoperative recurrence of endometrial carcinoma; human epididymis protein 4（ HE 4） is sensitive to the incidence of the diseases,while advanced age is a restriction to such sensitivity; angiotensin Ⅱ is superior in the prognosis judgement of endometrial carcinoma. Here is to make a review of the advantages and disadvantages of the three tumor markers mentioned above which have been studied the most in recent years,and the application prospect of combined detection of those tumor markers.