摘要
胰岛素样生长因子1(IGF-1)是一种具有促进物质代谢和细胞分裂等功能的细胞增殖调控因子,主要由肝脏产生,通过自分泌和(或)旁分泌的方式发挥作用。IGF-1参与了正常细胞增殖、凋亡以及器官的生长和发育过程,且与肿瘤的形成、发展、侵入和转移密切相关。近年来有研究表明,IGF-1与其受体(IGF-1R)在甲状腺相关疾病的发生和发展中起到了重要的作用,故可能成为临床治疗新的靶点。
Insulin-like growth factor 1（ IGF-1）,a kind of cell proliferation regulatory factor,can promote metabolism and cellular fission. IGF-1 is mainly produced by the liver,and plays its role through autocrine and / or paracrine. IGF-1 is not only involved in normal cell proliferation,apoptosis,and growth and development of organs,but also closely related to tumor formation,development,invasion and metastasis. In recent years,studies have shown that IGF-1 and IGF-1 receptor（ IGF-1R） play an important role in thyroid-related diseases,which may become a potential target for clinical treatment.
出处
《医学综述》
2015年第3期409-411,共3页
Medical Recapitulate
